Table 1.
Genes included in STRAC11, STRAC13, and STRAC14
| Gene | Class/Function | |
|---|---|---|
| STRAC13 and STRAC11 | AMT | Aminomethyltransferase (Glycine Cleavage System Protein T) |
| STRAC13 | CXCR1 | High Affinity Interleukin-8 Receptor A; recruits immune suppressive cells such as the myeloid-derived suppressor cells to the tumor microenvironment |
| ATG14 | Autophagy-Related Protein 14-Like Protein; regulates cytoprotective autophagy (role in drug resistance) | |
| FPR2 | Formyl Peptide Receptor 2; promotes invasion and metastasis of some cancers | |
| SPIN3 | Spindlin-Like Protein 3; a tumor suppressor, pro-apoptotic, downregulates CYCD1 | |
| ZNF415 | Zinc Finger Protein 415; involved in transcriptional regulation; promoter aberrantly hypermethylated in oropharyngeal squamous cell carcinoma | |
| THEM4 | Thioesterase Superfamily Member 4; facilitates apoptosis by negatively regulating Akt/PKB signaling | |
| TXNIP | Thioredoxin Interacting Protein; a tumor suppressor in various cancers; regulate the metabolism and division of cells by inhibiting their ability to take up glucose | |
| ADHFE1 | Hydroxyacid-Oxoacid Transhydrogenase; a breast cancer oncogene | |
| UFSP1 | UFM1-Specific Peptidase 1 (non-functional) | |
| ZKSCAN7 | Zinc Finger With KRAB And SCAN Domains 7; may be involved in transcriptional regulation | |
| BIRC7 | Baculoviral IAP Repeat Containing 7; inhibits apoptosis by inhibiting proteolytic activation of capsases | |
| HIST2H3A | H3 Clustered Histone 15; core component of nucleosome | |
| STRAC11 | APOBEC3A | Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3A; induces mutagenesis in cancer cells, and contributes to tumor evolution |
| PRKAB1 | Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1; a regulatory subunit of the AMP-activated protein kinase (AMPK), can act as either a tumor suppressor (prevent tumorigenesis) or a tumor promoter (after tumorigenesis occurred) | |
| MROH8 | Maestro Heat Like Repeat Family Member 8 | |
| SLPI | Secretory Leukocyte Peptidase Inhibitor; modulates the inflammatory and immune responses and the promotion of cell proliferation | |
| TDO2 | Tryptophan 2,3-Dioxygenase; may play a role in cancer through the suppression of antitumor immune responses | |
| SNX29 | Sorting Nexin 29; circular RNA derived from this gene reduced myoblast proliferation and promoted cell differentiation | |
| SLC16A1 | Solute Carrier Family 16 Member 1; a key controller of the cell cycle and mitosis, oncogene role in promoting cancer cell proliferation | |
| MERTK | MER Proto-Oncogene, Tyrosine Kinase; regulates cell survival, migration, differentiation, and phagocytosis of apoptotic cells; increases tumor immunogenicity | |
| ARRDC1 | Arrestin Domain-Containing 1; a tumor suppressor in ccRCC in the Hippo pathway | |
| STEAP1 | Six Transmembrane Epithelial Antigen Of The Prostate 1; promotes proliferation, migration, invasiveness, and tumorigenicity | |
| STRAC14 | ECE2 | Endothelin Converting Enzyme 2; involved in the processing of various neuroendocrine peptides |
| TMEM220 | Transmembrane Protein 220 | |
| TOMM40 | Translocase of Outer Mitochondrial Membrane 40; essential for import of protein precursors into mitochondria | |
| NDUFS6 | NADH:Ubiquinone Oxidoreductase Subunit S6; interact with CD147 in the mitochondria and may play a role in the multidrug resistance of cancer cells | |
| NEB | Nebulin; muscle protein that may be involved in maintaining the structural integrity of sarcomeres and the myofibril’s membrane | |
| ZNF727 | Zinc Finger Protein 727; may be involved in transcriptional regulation | |
| IRF6 | Interferon Regulatory Factor 6; may be a transcriptional activator | |
| ZNF483 | Zinc Finger Protein 483; may be involved in transcriptional regulation | |
| ACHE | Acetylcholinesterase (Cartwright Blood Group); has a role in neuronal apoptosis | |
| LIPC | Hepatic Triacylglycerol Lipase; plays a role in in cancer progression and metastasis | |
| RAB3IL1 | RAB3A Interacting Protein Like 1; may have a role in synaptic vesicle exocytosis | |
| SAMD15 | Sterile Alpha Motif Domain-Containing 15 | |
| MTMR8 | Myotubularin Related Protein 8; in complex with MTMR9, negatively regulates autophagy | |
| PKP1 | Plakophilin 1; may be involved in molecular recruitment and stabilization during desmosome formation |
STRAC11, 13, 14 gene expression signatures of 11, 13, and 14 genes.