Table 1.
Base-line characteristics in relation to BMI in the 35,412 postmenopausal patients in the KARMA Cohort
| Variable | Overall | < 18.5 | ≥ 18.5- < 25 | ≥ 25- < 30 | ≥ 30 | Missing |
|---|---|---|---|---|---|---|
| No. of women (%) | 35 412 (100) | 374 (1%) | 17 890 (51%) | 12 029 (34%) | 4693 (13%) | 426 (1%) |
| Age at entry, years (median [IQR]) | 62 [57, 67] | 63 [59, 68] | 62 [56, 67] | 62 [57, 67] | 62 [57, 67] | 62 [58, 67] |
| Age at entry, years (%) | ||||||
| ≤ 29 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| 30–39 | 17 (0.0) | 0 (0.0) | 7 (0.0) | 7 (0.1) | 3 (0.1) | 0 (0.0) |
| 40–49 | 1137 (3.2) | 17 (4.5) | 623 (3.5) | 317 (2.6) | 166 (3.5) | 14 (3.3) |
| 50–59 | 12 403 (35.0) | 92 (24.6) | 6579 (36.8) | 4017 (33.4) | 1567 (33.4) | 148 (34.7) |
| 60–69 | 17 400 (49.1) | 198 (52.9) | 8573 (47.9) | 6092 (50.6) | 2331 (49.7) | 206 (48.4) |
| 70–79 | 4431 (12.5) | 67 (17.9) | 2094 (11.7) | 1588 (13.2) | 624 (13.3) | 58 (13.6) |
| ≥ 80 | 24 (0.1) | 0 (0.0) | 14 (0.1) | 8 (0.1) | 2 (0.0) | 0 (0.0) |
| Height, cm (median [IQR]) | 166 [162, 170] | 167 [163, 171] | 167 [162, 170] | 165 [162, 170] | 165 [161, 169] | NA [NA, NA] |
| Weight, kg (median [IQR]) | 68 [62, 77] | 50 [47, 52] | 62 [58, 67] | 74 [70, 79] | 89 [83, 96] | NA [NA, NA] |
| BMI at entry, kg/m2 (median [IQR]) | 24.8 [22.6, 27.7] | 18.0 [17.6, 18.3] | 22.7 [21.4, 23.8] | 26.9 [25.9, 28.1] | 32.3 [30.9, 34.7] | NA [NA, NA] |
| Age at menarche, years (median [IQR]) | 13 [12, 14] | 13 [12, 14] | 13 [12, 14] | 13 [12, 14] | 13 [12, 14] | 13 [12, 14] |
| Age at menarche, missing (%) | 1261 (3.6) | 25 (6.7) | 495 (2.8) | 361 (3.0) | 146 (3.1) | 234 (54.9) |
| Age at menopause, years (median [IQR]) | 50.0 [47.0, 53.0] | 50.0 [47.5, 53.0] | 50.0 [48.0, 53.0] | 50.0 [47.0, 53.0] | 50.0 [47.0, 53.0] | 50.0 [47.0, 52.3] |
| Age at menopaus, missing (%) | 18 161 (51.3) | 203 (54.3) | 9042 (50.5) | 6146 (51.1) | 2408 (51.3) | 362 (85.0) |
| No. of pregnancies (%) | ||||||
| 0 | 3057 (8.6) | 53 (14.2) | 1623 (9.1) | 915 (7.6) | 438 (9.3) | 28 (6.6) |
| 1 | 3934 (11.1) | 55 (14.7) | 1989 (11.1) | 1318 (11.0) | 545 (11.6) | 27 (6.3) |
| 2 | 11 371 (32.1) | 106 (28.3) | 5833 (32.6) | 3921 (32.6) | 1473 (31.4) | 38 (8.9) |
| 3 | 8656 (24.4) | 91 (24.3) | 4347 (24.3) | 3051 (25.4) | 1137 (24.2) | 30 (7.0) |
| ≥ 4 | 7591 (21.4) | 58 (15.5) | 3853 (21.5) | 2636 (21.9) | 1012 (21.6) | 32 (7.5) |
| Missing | 803 (2.3) | 11 (2.9) | 245 (1.4) | 188 (1.6) | 88 (1.9) | 271 (63.6) |
| No. of births (%) | ||||||
| 0 | 4331 (12.2) | 69 (18.4) | 2315 (12.9) | 1304 (10.8) | 607 (12.9) | 36 (8.5) |
| 1 | 5232 (14.8) | 73 (19.5) | 2619 (14.6) | 1784 (14.8) | 723 (15.4) | 33 (7.7) |
| 2 | 16,048 (45.3) | 134 (35.8) | 8211 (45.9) | 5625 (46.8) | 2025 (43.1) | 53 (12.4) |
| 3 | 7084 (20.0) | 71 (19.0) | 3605 (20.2) | 2442 (20.3) | 942 (20.1) | 24 (5.6) |
| ≥ 4 | 1911 (5.4) | 16 (4.3) | 893 (5.0) | 684 (5.7) | 309 (6.6) | 9 (2.1) |
| Missing | 806 (2.3) | 11 (2.9) | 247 (1.4) | 190 (1.6) | 87 (1.9) | 271 (63.6) |
| Age at first birth (%) | ||||||
| ≤ 20 | 4195 (11.8) | 23 (6.1) | 1627 (9.1) | 1717 (14.3) | 805 (17.2) | 23 (5.4) |
| > 20- ≤ 25 | 11 315 (32.0) | 107 (28.6) | 5463 (30.5) | 4041 (33.6) | 1659 (35.4) | 45 (10.6) |
| > 25- ≤ 30 | 9645 (27.2) | 99 (26.5) | 5344 (29.9) | 3163 (26.3) | 1006 (21.4) | 33 (7.7) |
| > 30 | 5107 (14.4) | 65 (17.4) | 2887 (16.1) | 1611 (13.4) | 526 (11.2) | 18 (4.2) |
| Nulliparous | 4331 (12.2) | 69 (18.4) | 2315 (12.9) | 1304 (10.8) | 607 (12.9) | 36 (8.5) |
| Missing | 819 (2.3) | 11 (2.9) | 254 (1.4) | 193 (1.6) | 90 (1.9) | 271 (63.6) |
| Age at first child birth, years (median [IQR]) | 25.0 [22.0, 29.0] | 26.0 [23.0, 30.0] | 26.0 [23.0, 29.0] | 25.0 [22.0, 28.0] | 24.0 [21.0, 28.0] | 25.0 [21.0, 28.0] |
| No. of women using oral contraceptives (%) | ||||||
| No | 6701 (18.9) | 91 (24.3) | 3241 (18.1) | 2304 (19.2) | 1031 (22.0) | 34 ( 8.0) |
| Yes | 27 308 (77.1) | 266 (71.1) | 14 101 (78.8) | 9323 (77.5) | 3494 (74.5) | 124 (29.1) |
| Missing | 1403 (4.0) | 17 (4.5) | 548 (3.1) | 402 (3.3) | 168 (3.6) | 268 (62.9) |
| No. of women using HRT (%) | ||||||
| No | 19 759 (55.8) | 209 (55.9) | 9871 (55.2) | 6715 (55.8) | 2833 (60.4) | 131 (30.8) |
| Yes | 14 797 (41.8) | 152 (40.6) | 7740 (43.3) | 5085 (42.3) | 1754 (37.4) | 66 (15.5) |
| Missing | 856 (2.4) | 13 (3.5) | 279 (1.6) | 229 (1.9) | 106 (2.3) | 229 (53.8) |
| No. of women with breast cancer in the family (%) | ||||||
| No | 28 789 (81.3) | 301 (80.5) | 14 738 (82.4) | 9822 (81.7) | 3766 (80.2) | 162 (38.0) |
| Yes | 5250 (14.8) | 60 (16.0) | 2644 (14.8) | 1788 (14.9) | 735 (15.7) | 23 (5.4) |
| Missing | 1373 (3.9) | 13 (3.5) | 508 (2.8) | 419 (3.5) | 192 (4.1) | 241 (56.6) |
| No. of smoking women (%) | ||||||
| Never | 14 172 (40.0) | 163 (43.6) | 7486 (41.8) | 4634 (38.5) | 1830 (39.0) | 59 (13.8) |
| Previous | 16 026 (45.3) | 118 (31.6) | 7885 (44.1) | 5726 (47.6) | 2233 (47.6) | 64 (15.0) |
| Current | 4342 (12.3) | 83 (22.2) | 2234 (12.5) | 1452 (12.1) | 544 (11.6) | 29 (6.8) |
| Missing | 872 (2.5) | 10 (2.7) | 285 (1.6) | 217 (1.8) | 86 (1.8) | 274 (64.3) |
| Smoking, packyears (median [IQR]) | 2.00 [0.00, 10.5] | 0.90 [0.00, 14.2] | 1.50 [0.00, 8.60] | 2.80 [0.00, 11.8] | 3.90 [0.00, 14.3] | 3.45 [0.00, 11.8] |
| No. of women drinking alcohol (%) | ||||||
| No | 6619 (18.7) | 88 (23.5) | 2789 (15.6) | 2224 (18.5) | 1475 (31.4) | 43 (10.1) |
| Yes | 27 686 (78.2) | 273 (73.0) | 14 707 (82.2) | 9515 (79.1) | 3084 (65.7) | 107 (25.1) |
| Missing | 1107 (3.1) | 13 (3.5) | 394 (2.2) | 290 (2.4) | 134 (2.9) | 276 (64.8) |
| Alcohol, gram per week (median [IQR]) | 37.0 [6.00, 67.0] | 36.0 [5.00, 68.0] | 37.0 [12.0, 68.00] | 37.0 [6.00, 68.0] | 24.0 [0.00, 49.0] | 24.5 [0.00, 48.8] |
| No. of women using statins (%) | ||||||
| No | 30 742 (86.8) | 349 (93.3) | 16 186 (90.5) | 10 152 (84.4) | 3684 (78.5) | 371 (87.1) |
| Yes | 4670 (13.2) | 25 (6.7) | 1704 (9.5) | 1877 (15.6) | 1009 (21.5) | 55 (12.9) |
| No. of women using insulin (%) | ||||||
| No | 34 985 (98.8) | 368 (98.4) | 17 774 (99.4) | 11 908 (99.0) | 4514 (96.2) | 421 (98.8) |
| Yes | 427 (1.2) | 6 (1.6) | 116 (0.6) | 121 (1.0) | 179 (3.8) | 5 (1.2) |
| No. of women using metformin (%) | ||||||
| No | 34 563 (97.6) | 374 (100.0) | 17 757 (99.3) | 11 735 (97.6) | 4283 (91.3) | 414 (97.2) |
| Yes | 849 (2.4) | 0 (0.0) | 133 (0.7) | 294 (2.4) | 410 (8.7) | 12 (2.8) |