Table 5.
Crude rates per 1000 person years, 8-year cumulative risk, crude and adjusted* hazard ratios for immunohistochemical surrogate marker subtype specific breast cancer in relation to BMI
| Postmenopausal patients | ||||||||
|---|---|---|---|---|---|---|---|---|
| Subtype | BMI | Persons | Cases | Person years | Crude rate per 1000 person years (95% CI) | 8-year cumulative risk (95% CI) |
Crude HR (95% CI) | Adjusted HR (95% CI) |
| ER+, HER2− | < 25 | 16 553 | 243 | 121 000 | 2.01 (1.76–2.28) | 1.55% (1.35–1.76%) | 1 (reference) | 1 (reference) |
| ≥ 25–< 30 | 10 809 | 185 | 78 800 | 2.35 (2.02–2.71) | 1.77% (1.53–2.05%) | 1.17 (0.97–1.41) | 1.17 (0.96–1.42) | |
| ≥ 30 | 4148 | 78 | 30 000 | 2.6 (2.05–3.24) | 1.94% (1.54–2.40%) | 1.29 (1.00–1.67) | 1.37 (1.05–1.78) | |
| ER+, HER2+ | < 25 | 16 553 | 22 | 121 000 | 0,18 (0.11–0.28) | 0.14% (0.09–0.21%) | 1 (reference) | 1 (reference) |
| ≥ 25–< 30 | 10 809 | 23 | 78 800 | 0.29 (0.19–0.44) | 0.22% (0.15–0.33%) | 1.60 (0.89–2.88) | 1.57 (0.87–2.83) | |
| ≥ 30 | 4148 | 7 | 30 000 | 0.23 (0.094–0.48) | 0.17% (0.08–0.34%) | 1.28 (0.55–3.00) | 1.19 (0.50–2.88) | |
| ER−, HER2+ | < 25 | 16 553 | 11 | 121 000 | 0.091 (0.045–0.16) | 0.07% (0.04–0.12%) | 1 (reference) | 1 (reference) |
| ≥ 25–< 30 | 10 809 | 3 | 78 800 | 0.038 (0.0079–0.11) | 0.03% (0.01–0.08%) | 0.42 (0.12–1.50) | 0.46 (0.13–1.65) | |
| ≥ 30 | 4148 | 3 | 30 000 | 0.10 (0.021–0.29) | 0.07% (0.02–0.21%) | 1.09 (0.31–3.92) | 1.35 (0.36–5.01) | |
| TNBC | < 25 | 16 553 | 26 | 121 000 | 0.22 (0.14–0.32) | 0.18% (0.12–0.27%) | 1 (reference) | 1 (reference) |
| ≥ 25–< 30 | 10 809 | 21 | 78 800 | 0.27 (0.17–0.41) | 0.21% (0.13–0.32%) | 1.24 (0.70–2.21) | 1.22 (0.68–2.19) | |
| ≥ 30 | 4148 | 4 | 30 000 | 0.13 (0.036–0.34) | 0.14% (0.05–0.36%) | 0.62 (0.22–1.78) | 0.61 (0.21–1.79) | |
| Luminal A | < 25 | 16 553 | 144 | 121 000 | 1.19 (1.00–1.40) | 0.86% (0.72–1.01%) | 1 (reference) | 1 (reference) |
| ≥ 25–< 30 | 10 809 | 116 | 78 800 | 1.47 (1.22–1.77) | 1.08% (0.90–1.29%) | 1.24 (0.97–1.58) | 1.23 (0.96–1.57) | |
| ≥ 30 | 4148 | 48 | 30 000 | 1.6 (1.18–2.12) | 1.16% (0.87–1.53%) | 1.34 (0.97–1.86) | 1.43 (1.02–2.01) | |
| Luminal B | < 25 | 16 553 | 79 | 121 000 | 0.65 (0.52–0.81) | 0.52% (0.41–0.66%) | 1 (reference) | 1 (reference) |
| ≥ 25–< 30 | 10 809 | 60 | 78 800 | 0.76 (0.58–0.98) | 0.56% (0.43–0.72%) | 1.17 (0.83–1.63) | 1.15 (0.82–1.62) | |
| ≥ 30 | 4148 | 26 | 30 000 | 0.87 (0.57–1.27) | 0.67% (0.44–0.97%) | 1.32 (0.85–2.06) | 1.33 (0.84–2.11) | |
*Adjusted for reproductive factors (age at menarche, use of HRT and oral contraceptives, age at first child birth, number of births, co-medications (insulin, metformin, and statins), heredity, and life-style factors (smoking and alcohol)