Table 2.

Association of polygenic risk scores and weighted sum scores with risk of MS.

Genetic risk score	Comparison	OR	Lower CI	Higher CI	Adjusted P value
Polygenic risk score	Familial MS cases versus Population controls	1.84	1.277	2.63	0.0077*
	Familial MS cases versus Control families	2.27	1.323	4.318	0.0491*
	Familial MS cases versus Unaffected relatives	2.61	1.322	6.085	0.1053
	Sporadic MS cases versus Familial MS cases	1.83	1.11	3.7	0.087
Weighted sum score	Familial MS cases versus Population controls	2.16	1.439	3.279	0.002*
	Familial MS cases versus Control families	2.4	1.447	4.327	0.014*
	Familial MS cases versus Unaffected relatives	1.64	0.909	3.16	1
	Sporadic MS cases versus Familial MS cases	0.82	0.45	1.44	0.95
Weighted sum score (non-MHC)	Familial MS cases versus Population controls	1.83	1.222	2.771	0.0324*
	Familial MS cases versus Control families	1.92	1.193	3.276	0.0972
	Familial MS cases versus Unaffected relatives	1.4	0.793	2.613	1
	Sporadic MS cases versus Familial MS cases	0.81	0.45	1.4	0.93

OR, odds ratio (95% confidence intervals [CI]); Adjusted P value, after Bonferroni correction; *, significant.