Table 3.

Changes of WOMAC, SF36, VAS, KSS and KSFS scores from baseline to follow-ups.

Variable	BM-MSCs				HA				Fixed effects (BM-MSCs Group)
	3 ​Months	6 ​Months	9 ​Months	12 ​Months	3 ​Months	6 ​Months	9 ​Months	12 ​Months	Effect size (95% CI)	p-value
ΔWOMAC a
Total score	−2.10 ​± ​15.54	−7.10 ​± ​24.22	−10.50 ​± ​18.16	−10.40 ​± ​17.41	8.50 ​± ​14.81	0.43 ​± ​22.32	13.43 ​± ​19.53	8.33 ​± ​20.33	−15.52 (−31.00, −0.04)	0.049
Pain score	−0.20 ​± ​4.05	−1.10 ​± ​5.76	−2.10 ​± ​5.26	−1.80 ​± ​4.52	1.63 ​± ​2.18	0.43 ​± ​3.21	2.57 ​± ​2.37	3.22 ​± ​3.23	−3.32 (−6.52, −0.12)	0.042
Stiffness	−0.10 ​± ​1.52	−0.70 ​± ​2.06	−0.90 ​± ​1.29	−0.50 ​± ​1.58	1.00 ​± ​2.45	−1.43 ​± ​2.94	−1.57 ​± ​2.44	0.33 ​± ​2.55	−0.44 (−2.30, 1.42)	0.641
Physical function	−1.80 ​± ​10.87	−5.30 ​± ​16.9	−7.50 ​± ​12.29	−8.10 ​± ​12.22	5.88 ​± ​13.17	−8.00 ​± ​25.77	3.00 ​± ​15.51	−2.56 ​± ​18.29	−5.18 (−18.60, 8.24)	0.444
Percetage Score	−2.19 ​± ​16.19	−7.40 ​± ​25.23	−10.94 ​± ​18.92	−10.83 ​± ​18.14	8.85 ​± ​15.43	0.45 ​± ​23.25	13.99 ​± ​20.34	8.68 ​± ​21.18	−16.17 (−32.30, −0.04)	0.049
ΔSF36a
PF	9.00 ​± ​7.38	11.50 ​± ​16.17	11.50 ​± ​20.69	7.00 ​± ​19.75	−1.25 ​± ​9.54	−11.43 ​± ​13.14	−11.43 ​± ​16.76	1.50 ​± ​11.80	14.38 (4.58, 24.18)	0.005
RP	0.63 ​± ​14.57	1.88 ​± ​17.44	3.75 ​± ​16.46	6.25 ​± ​17.92	3.13 ​± ​10.02	8.03 ​± ​10.02	6.25 ​± ​7.22	3.13 ​± ​6.75	−1.31 (−12.26, 9.65)	0.812
BP	14.25 ​± ​20.21	22.25 ​± ​27.85	23.25 ​± ​16.75	22.50 ​± ​18.07	−9.06 ​± ​8.86	5.00 ​± ​35.68	−4.64 ​± ​14.75	−8.75 ​± ​19.59	25.26 (7.69, 42.82)	0.005
GH	−4.00 ​± ​12.87	−1.00 ​± ​8.10	−2.00 ​± ​7.53	−0.50 ​± ​8.32	3.75 ​± ​9.54	4.00 ​± ​10.84	3.00 ​± ​13.04	−0.50 ​± ​12.35	−1.82 (−9.87, 6.22)	0.652
VT	1.25 ​± ​16.35	5.00 ​± ​18.35	3.75 ​± ​17.73	3.13 ​± ​18.69	−6.25 ​± ​20.04	−6.25 ​± ​18.75	−2.68 ​± ​21.61	−4.38 ​± ​26.52	10.00 (−6.84, 26.83)	0.240
SF	5.00 ​± ​16.87	3.75 ​± ​18.68	8.75 ​± ​22.86	8.75 ​± ​26.39	0 ​± ​6.68	−7.50 ​± ​14.25	−10.00 ​± ​13.69	−2.50 ​± ​9.86	10.16 (−3.54, 23.87)	0.143
RE	−5.00 ​± ​15.32	−4.17 ​± ​9.00	−4.17 ​± ​7.08	−3.33 ​± ​11.92	3.12 ​± ​6.20	0 ​± ​4.81	2.38 ​± ​11.5	2.50 ​± ​7.91	−5.86 (−13.16, 1.45)	0.114
MH	0 ​± ​12.73	5.42 ​± ​13.18	1.67 ​± ​11.98	0 ​± ​12.73	−9.90 ​± ​14.59	−1.67 ​± ​15.76	1.19 ​± ​10.13	−3.33 ​± ​18.72	6.50 (−6.22, 19.22)	0.311
PCS	4.97 ​± ​4.46	8.66 ​± ​12.68	9.13 ​± ​9.27	8.81 ​± ​9.84	−0.86 ​± ​3.52	0.97 ​± ​9.41	−3.26 ​± ​6.62	−1.16 ​± ​8.31	9.03 (2.81, 15.25)	0.005
MCS	0.31 ​± ​11.62	2.50 ​± ​10.78	2.50 ​± ​11.14	2.14 ​± ​11.46	−3.25 ​± ​7.76	−9.60 ​± ​12.02	−7.27 ​± ​7.94	−1.93 ​± ​11.5	7.70 (−0.24, 15.65)	0.057
ΔVASa
At Rest	−0.30 ​± ​1.57	−0.50 ​± ​2.99	−0.70 ​± ​3.56	−0.50 ​± ​3.78	1.67 ​± ​2.34	2.43 ​± ​1.99	2.57 ​± ​1.51	2.70 ​± ​2.06	−2.91 (−4.98, −0.84)	0.007
With a burden	−0.85 ​± ​2.36	−1.55 ​± ​3.11	−1.55 ​± ​2.81	−1.65 ​± ​2.81	1.17 ​± ​2.14	2.00 ​± ​2.52	2.14 ​± ​2.04	1.55 ​± ​2.17	−2.93 (−4.85, −1.02)	0.003
During Physical Activity	−1.60 ​± ​2.88	−1.55 ​± ​3.55	−1.55 ​± ​3.32	−1.65 ​± ​3.18	−0.17 ​± ​0.75	−0.57 ​± ​1.90	0.71 ​± ​1.25	0.45 ​± ​2.14	−1.71 (−3,91, 0.49)	0.126
ΔKSSa	11.80 ​± ​20.68	17.50 ​± ​18.48	16.60 ​± ​21.88	17.20 ​± ​22.58	13.00 ​± ​10.76	10.00 ​± ​16.48	5.90 ​± ​18.56	3.90 ​± ​21.08	7.10 (−7.99, 22.19)	0.351
ΔKSFSa	0.50 ​± ​11.65	5.50 ​± ​11.17	8.00 ​± ​12.29	11.50 ​± ​18.57	2.00 ​± ​7.89	3.33 ​± ​11.18	2.00 ​± ​10.33	−1.00 ​± ​16.63	4.81 (−3.88, 13.50)	0.274

^aChanges of the scores from baseline to follow-ups.