Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 10;13:5859. doi: 10.1038/s41467-022-33605-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — a Intraperitoneal (i.p.) injection of 4-phenylbutyric acid (4-PBA; 200 mg/kg/day) suppresses Lens-induced myopia (LIM)-induced activation in UPR branch determined by Western blotting in sclerae. NL: No Lens control, −30D: minus 30 D lens-wearing eye. b Densitometric quantification of blots in Fig. 2a using ImageJ. PBS-NL group was assigned a value of 1.0. Each group were n = 4 (each sample pooled 3 sclerae). The p values were determined by two-tailed Generalized Estimating Equations. c LIM-induced axial elongation is inhibited by 4-PBA administration for 3 weeks (n = 6 per group); **p < 0.01 (p = 0.001), ***p < 0.001; two-tailed Generalized Estimating Equations. d LIM-induced myopic shift in refraction is inhibited by 4-PBA administration for 3 weeks (n = 6 per group); ***p < 0.001; two-tailed Generalized Estimating Equations. e Eye drop administration of 4-PBA (2% solution in PBS) during LIM period (to both eyes) suppresses LIM-induced activation in UPR branch determined by Western blotting in sclerae. f Densitometric quantification of blots in Fig. 2e using ImageJ.PBS-NL group was assigned a value of 1.0. Each group were n = 4 (each sample pooled 3 sclerae). ***p < 0.001; two-tailed Generalized Estimating Equations. g 4-PBA instillation suppresses axial elongation in a dose-dependent manner (n = 4 per group); ***p < 0.001; two-tailed Generalized Estimating Equations. h 4-PBA instillation suppresses myopic shift in refraction in a dose-dependent manner (n = 4 per group); ***p < 0.001; two-tailed Generalized estimating equations. Source data are provided as a Source Data file.