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. 2022 Oct 10;13:5859. doi: 10.1038/s41467-022-33605-1

Fig. 5. Inhibition of both PERK and ATF6 pathways suppresses myopia progression caused by negative lens wearing.

Fig. 5

a Effects of combined STF, GSK, and NFV instillation (S + G: STF and GSK, G + N: GSK and NFV, N + S: NFV and STF; 100 μM each) on LIM-induced activation of IRE1, eIF2, and ATF6 in sclerae. NL: No Lens control, −30D: minus 30 D lens-wearing eye. b Densitometric quantification of blots in Fig. 5a using ImageJ. DMSO-NL group was assigned a value of 1.0. Each group were n = 4 (each sample pooled 3 sclerae). The p values were determined by two-tailed Generalized Estimating Equations for four groups comparison (DMSO vs S + G vs G + N vs N + S in each eye) and Student’s two-tailed t-test for NL and −30D eyes comparison in each treatment. NS: Not Significant. c Effects of combined STF, GSK, and NFV instillation on axial elongation in NL and −30 D eyes (n = 4 per group); ***p < 0.001 compared to the DMSO group; two-tailed Generalized Estimating Equations. d Effects of combined STF, GSK, and NFV instillation on refraction in NL and −30 D eyes (n = 4 per group); *p < 0.05 (p = 0.011), **p < 0.01 (p = 0.005), ***p < 0.001 compared to the DMSO group; two-tailed Generalized Estimating Equations. Source data are provided as a Source Data file.