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. 2022 Oct 10;13:5859. doi: 10.1038/s41467-022-33605-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Effect of PERK agonist CCT020312 (CCT) and ATF6 agonist AA147 (AA) instillation on IRE1, eIF2 and ATF6 activity in sclera. One hour after eye drop, the sclerae were harvested and subjected to Western blotting. Each compound specifically activated each pathway. b GRP78, ATF4, and EDEM gene expression induced by CCT. Each zero group was assigned a value of 1.0. *p = 0.029, compared to 0 (as a control) group; one-way ANOVA with Tukey HSD (n = 4, respectively). c GRP78, ATF4, and EDEM gene expression induced by AA. Each zero group was assigned a value of 1.0. *p = 0.013, compared to 0 (as a control) group; one-way ANOVA with Tukey HSD (n = 4, respectively). d Effects of 1-week instillation of CCT (100 μM) instillation on refraction; ***p = 0.00055; Student’s two-tailed t-test. e Effects of 1-week instillation of AA (100 μM) instillation on refraction; *p = 0.016; Student’s two-tailed t-test. f Effects of 1-week instillation of CCT plus AA (100 μM, respectively) instillation on refraction; ***p = 0.00001; Student’s two-tailed t-test. g Effects of 1-week instillation of CCT instillation on axial length; *p = 0.041; Student’s two-tailed t-test. h Effects of 1-week instillation of AA instillation on axial length; *p = 0.015; Student’s two-tailed t-test. i Effects of 1-week instillation of CCT plus AA instillation on axial length; ***p = 0.00039; Student’s two-tailed t-test. j Effects of 1-week instillation of CCT instillation on VCD + RT. *p = 0.036; Student’s two-tailed t-test. k Effects of 1-week instillation of AA instillation on VCD + RT. *p = 0.024; Student’s two-tailed t-test. l Effects of 1-week instillation of CCT plus AA instillation on axial length; ***p = 0.0004; Student’s two-tailed t-test. Source data are provided as a Source Data file.