Skip to main content
. Author manuscript; available in PMC: 2023 Mar 23.
Published in final edited form as: Best Pract Res Clin Endocrinol Metab. 2022 Apr 11;37(2):101661. doi: 10.1016/j.beem.2022.101661

Figure 2:

Figure 2:

3-D structure of the HLA-DRβ-Arg74 pocket with Cepharanthine bound to it. As can be seen, Cepharanthine interacts with the arginine at position β74. Arg74 (shown in yellow) is proximal to the oxygen atoms in Cepharanthine (shown in Van der Waals spheres). Therefore, Cepharanthine can prevent Tg and TSHR peptides from binding to the pocket and being presented to T-cells.