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Models of craniofacial disorders arising from disruption in Pol I transcription. Hypoplasia of NCC derived skeletal elements is present in AFDCIN and TCS (B) compared to unaffected individuals (A). Cartilage and bone staining reveals hypoplasia of skeletal elements in mouse models of TCS (C) and zebrafish models of AFDCIN and TCS (D). Arrowheads indicate areas of mandibular hypoplasia.
