Table 1.
Patient Characteristics for the Entire Cohort and by FIB-4 Risk Category
| Characteristics | Total | FIB-4 risk category | p-value | ||
|---|---|---|---|---|---|
| Low | Indeterminate | High | |||
| ≤ 1.3 | 1.31–2.67 | > 2.67 | |||
| n=20,556 | n=13,127 | n=6,012 | n=1,417 | ||
| Age (mean ± SD) | 51.0 ± 16.6 | 44.2 ± 14.6 | 62.8 ± 12.1 | 64.2 ± 15.0 | <0.001* |
| Gender (%) | <0.001† | ||||
| Female | 64.8 | 71.6 | 54.6 | 44.3 | |
| Male | 35.2 | 28.4 | 45.4 | 55.7 | |
| Race (%) | <0.001† | ||||
| Black | 45.3 | 46.1 | 43.1 | 46.4 | |
| Other | 2.6 | 3.0 | 1.7 | 2.3 | |
| White | 52.2 | 50.9 | 55.2 | 51.2 | |
| Marital status (%) | <0.001† | ||||
| Married | 45.5 | 44.4 | 49.1 | 40.2 | |
| Unmarried | 54.5 | 55.6 | 50.9 | 59.8 | |
| Current smoker (% yes) | 12.5 | 13.5 | 10.1 | 14.0 | <0.001† |
| BMI (mean ± SD) | 29.8 ± 8.2 | 30.6 ± 8.5 | 28.7 ± 7.3 | 27.5 ± 6.9 | <0.001* |
| Hypertension (%) | 67.1 | 60.3 | 78.9 | 79.8 | <0.001† |
| Diabetes (%) | 29.5 | 27.1 | 33.5 | 35.1 | <0.001† |
| Hyperlipidemia (%) | 54.4 | 47.3 | 69.4 | 56.9 | <0.001† |
| Cardiovascular disease (%) | 26.5 | 21.0 | 35.0 | 40.9 | <0.001† |
| Hypothyroidism (%) | 16.0 | 15.2 | 17.5 | 17.2 | <0.001† |
| Kidney disease (%) | 18.4 | 13.6 | 25.3 | 33.6 | <0.001† |
| Chronic liver disease (%) | <0.001† | ||||
| None | 89.0 | 91.1 | 88.2 | 73.0 | <0.001† |
| NAFLD | 2.3 | 2.4 | 2.2 | 2.5 | 0.6536† |
| Other Liver Dx | 8.2 | 6.2 | 9.1 | 23.2 | <0.001† |
| NAFLD + Other Liver Dx | 0.5 | 0.4 | 0.5 | 1.3 | <0.001† |
*One-way analysis of variance (ANOVA) test to compare means across the 3 risk categories. †Chi-square tests used to compare proportions across the FIB-4 risk categories. FIB-4, Fibrosis-4 Index; SD, standard deviation; BMI, body mass index (kg/m2); NAFLD, nonalcoholic fatty liver disease; Dx, diagnosis