TABLE 5.

Effect modification of TG on the association between eGFR and NAFLD risk.

Incident NAFLD	Crude model	Model I	Model II
	HR (95% CI) P-value	HR (95% CI) P-value	HR (95% CI) P-value
eGFR as a continuous variable
TG group
<1.7 mmol/L	0.978 (0.976, 0.980) <0.0001	0.984 (0.981, 0.986) <0.0001	0.981 (0.978, 0.984) <0.0001
≥1.7 mmol/L	0.989 (0.986, 0.991) <0.0001	0.989 (0.986, 0.992) <0.0001	0.986 (0.983, 0.989) <0.0001
P value for interaction	<0.0001	0.0097	0.0139
eGFR as a categorical variables
TG group
TG<1.7 mmol/L
eGFR quartile
<82.88	Ref.	Ref.	Ref.
≥82.88,<99.70	0.702 (0.609, 0.809) <0.0001	0.808 (0.698, 0.936) 0.0044	0.816 (0.703, 0.946) 0.0071
≥99.70, <116.56	0.407 (0.347, 0.479) <0.0001	0.584 (0.492, 0.693) <0.0001	0.580 (0.487, 0.690) <0.0001
≥116.56	0.235 (0.196, 0.283) <0.0001	0.393 (0.320, 0.482) <0.0001	0.387 (0.313, 0.478) <0.0001
TG≥1.7 mmol/L
eGFR quartile
<82.88	Ref.	Ref.	Ref.
≥82.88, <99.70	0.816 (0.697, 0.955) 0.0112	0.816 (0.691, 0.963) 0.0159	0.731 (0.617, 0.865) 0.0003
≥99.70, <116.56	0.696 (0.583, 0.830) <0.0001	0.726 (0.601, 0.877) 0.0009	0.642 (0.529, 0.779) <0.0001
≥116.56	0.438 (0.350, 0.549) <0.0001	0.447 (0.350, 0.572) <0.0001	0.380 (0.296, 0.488) <0.0001
P value for interaction	<0.0001	0.0388	0.0694

Crude model: we did not adjust other covariants. Model I: we adjusted age, sex, BMI, SBP, DBP. Model II: we adjusted age, sex, BMI, SBP, DBP, ALT, ALB, GLB, BUN, FBG, HDL-c, LDL-c.

CI, confidence; Ref, reference; eGFR, estimated glomerular filtration rate (mL/min⋅1.73 m²); TG, triglycerides (mmol/L).