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. 2022 Oct 10;12:439. doi: 10.1038/s41398-022-02208-1

Fig. 3. LXA4 attenuates inflammation-induced memory failure and cytokine production in mice.

Fig. 3

a Freezing (seconds) of control or LPS-injected mice (0.3 mg/kg) treated with vehicle or 1 pmol LXA4 (i.c.v) in the contextual fear conditioning task. b–e Brain and plasma levels of IL-1β (b, c) or IL-6 (d, e) in control or LPS-injected mice (0.3 mg/kg; i.p.) treated with vehicle or 1 pmol LXA4 (i.c.v). Two-tailed unpaired two-way ANOVA followed by Holm–Šidák post hoc test (*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001). Graphs show means ± standard error of the mean (SEM).