FIGURE 5.

CircPTPRM aggravates PTC cell malignant phenotypes by regulating miR‐885‐5p/DNMT3A signaling axis. (A) The transfection efficiency of DNMT3A overexpression vector was confirmed by western blotting; After circPTPRM knockdown and/or DNMT3A overexpression, DNMT3A protein levels were determined by western blot (B); cell viability was determined by CCK‐8 assay (C); the migratory and invasion capabilities of TPC‐1 and KTC‐1 cells were evaluated by Transwell assays (D and E); the protein levels of E‐cadherin, N‐cadherin, and Vimentin were determined by western blot (F,G). Data are expressed as the mean ± SD. ^# p < 0.05, ^**;## p < 0.01, ^***;### p < 0.001 considered as significant.