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. 2022 Sep 27;9:868812. doi: 10.3389/fmed.2022.868812

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Copyright © 2022 Olaisen, Richard, Beisvåg, Granlund, Røyset, Rué, Martinsen, Sandvik, Sokol and Fossmark.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The mucosa-associated mycobiota in Crohn's disease (CD) patients (n = 44) was altered in comparison to healthy controls (HC) (n = 40). (A) Alpha-diversity, according to observed operational taxonomic units (OTUs) (left) and Simpson index (right), boxplots colored according to disease phenotype (HC = red, CD = blue). (B) Beta-diversity. Principal coordinates analysis of Bray–Curtis dissimilarity with samples colored according to study group, (CD = blue and HC = red). The fraction of diversity captured by the coordinate is given in percentage on axes 1 and 2. Groups were compared using the Permanova method. (C) Relative abundance of fungal phyla in HC and CD patients.