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. 2022 Sep 27;13:931384. doi: 10.3389/fphar.2022.931384

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Copyright © 2022 Chesworth, Cheng, Staub and Karl.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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No effect of long-term CBD on recall of spatial memory. Percentage [%] of time spent in the target zone at A probe test in APPxPS1 and WT mice treated daily with 20 mg/kg CBD for 8 months. Data were analysed using a single sample t-test against chance levels, i.e., 12.5%, corresponding to 1/8 zones. Data presented as mean ± SEM. Significant t-tests against chance are indicated by asterisks (*p < 0.05; **p < 0.01). N = 13 WT VEH, 16 APPxPS1 VEH, 14 WT CBD, and 10 APPxPS1 CBD. Abbreviations: APPxPS1: amyloid precursor protein x presenilin 1; CBD: cannabidiol; VEH: vehicle; WT: wildtype-like.