FIGURE 8.

Co-administration of selective CB ₂ R PAM EC21a doesn’t modify the effects of JR64a on the release of IL-6 in HMC3 cells exposed to LPS/TNFα stimulus. Bars represent the release (pg/ml) of IL-6 in the presence of the compounds. Data represent mean ± SEM from n = 3 independent experiments performed in duplicate. Statistical analysis was performed by ordinary one-way ANOVA followed by Tukey’s multiple comparison test. ^### p < 0.005 vs. control cells; ***p < 0.005 vs. LPS/TNFα treated cells.