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Synthetic pathway for the synthesis of the intermediate 5. Reagents and conditions: i) a) DMF, Cs₂CO₃, 1h, rt; b) p-fluorobenzyl bromide, 50°C, 12h; c) NaOH 10%, 100°C, 24 h; ii) a) DMF, NEt₃, TBTU, 0°C, 30 min.; b) cis-4-(Boc-amino) cyclohexylamine, 0°C, 30 min.; c) rt, 12 h; iii) CH₂Cl₂, CF₃COOH, −20°C, 3h; iv) a) 5-azidopentanoic acid, DMF, NEt₃, TBTU, 0°C, 30 min.; b) compound 4, 0°C, 30 min.; c) rt, 12h.
