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. 2022 Sep 27;10:984069. doi: 10.3389/fchem.2022.984069

SCHEME 2.

SCHEME 2

Synthetic pathway for the synthesis of the intermediates 7-11. Reagents and conditions: i) a) CsF, DMF, rt, 1h; b) suitable R-Br or R-Cl, 30 °C, 24 h; ii) NaN3, DMF, 60 °C, 12 h.