Table 2.
Frequency distribution for CD14 gene SNP (rs2569190) genotype/minor allele and its genetic association for Alcoholic liver disease.
| Gene/SNP | Genotype, Minor allele | Case (a)ALD, %n = 128 |
HWEχ2P-value | Control (b)ALC, %n = 184 |
HWEP-value | Control (c)NALC, %n = 152 |
HWEP-value | |
|---|---|---|---|---|---|---|---|---|
| CD14 rs2569190 (C/T) |
CC CT TT T |
26 (20.3) 64 (50.0) 38 (29.7) 0.547 |
χ2, 0.010 p, 0.920 |
63 (34.3) 79 (42.9) 42 (22.8) 0.443 |
χ2, 3.108 p, 0.078 |
53 (34.9) 60 (39.5) 39 (25.6) 0.454 |
χ2, 6.311 p, 0.012 |
|
| a. Test for deviations from Hardy–Weinberg equilibrium | ||||||||
| Gene/SNP | Genotype,Minor allele | ALD vs. ALCOR (95% CI) | P-value | ALD vs. NALCOR (95% CI) | P-value | ALD vs. ALC + NALCOR (95% CI) | P-value | |
| CD14 rs2569190 (C/T) |
CC CT TT CT+TT C T |
Ref 1.96 [1.12–3.45] 2.19 [1.16–4.13] 2.04 [1.21–3.46] Ref 1.52 [1.10–2.09] |
0.018 0.014 0.007 0.011 |
Ref 2.17 [1.21–3.91] 1.99 [1.04–3.80] 2.10 [1.22–3.62] Ref 1.45 [1.04–2.03] |
0.009 0.037 0.007 0.028 |
Ref 2.05 [1.22–3.45] 2.09 [1.18–3.72] 2.07 [1.27–3.36] Ref 1.48 [1.11–1.98] |
0.006 0.011 0.003 0.007 |
|
| b. Test for genetic association | ||||||||
*OR, 95% CI and p-value obtained from 2 × 2 Chi-square test for Association.
Bold values are statistically significant.