Skip to main content
. 2022 Sep 27;9:1027912. doi: 10.3389/fmolb.2022.1027912

TABLE 4.

Nrf2-regulated iron and glutathione metabolism related genes.

Gene abbreviation Gene name Involved metabolism
ABCB6 ATP binding cassette subfamily B member 6 Heme anabolism (Kerins and Ooi, 2018)
FECH ferrochelatase Heme anabolism (Kerins and Ooi, 2018)
SLC48A1/HRG1 Heme sensitive gene1 Heme catabolism (Kerins and Ooi, 2018)
HMOX-1 heme oxygenase Heme catabolism (Kerins and Ooi, 2018)
BLVRB biliverdin reductase B Heme catabolism (Kerins and Ooi, 2018)
AMBP alpha-1-microglobulin/bikunin precursor Heme catabolism (Kerins and Ooi, 2018)
FTH1/FTL ferritin heavy chain/light chain iron storage (Kerins and Ooi, 2018)
FPN1 ferroportin1 iron mobilization (Kerins and Ooi, 2018)
GCL glutamate–cysteine ligase GSH anabolism (Lu, 2013)
GS glutaminesynthetase GSH anabolism (Lu, 2013)
SLC7A11 Solute Carrier Family 7 GSH anabolism (Dong et al., 2020)
GPX4 glutathione peroxidase 4 GSH reduction (Wang Q. et al., 2021)
GSR Glutathione Reductase GSH reduction (Hoffmann et al., 2017)
TXNRD1 Thioredoxin Reductase 1 GSH anabolism (Gao et al., 2020)
SCD1 Stearyl coenzyme A dehydrogenase-1 fatty acid metabolism (Huang et al., 2010)
MT1G metallothionein (MT)-1G MT1G-Nrf2/MT1G-P53-P21pathway (Sun et al., 2016)
G6PD glucose-6-phosphate dehydrogenase Pentose phosphate pathway (Dodson et al., 2019)