Table 3.
Stratified analyses between miR-146a rs2910164 polymorphism and T2DM risk by gender, age, and BMI.
| Variable | Case/Control | OR (95% CI); P | |||||
|---|---|---|---|---|---|---|---|
| CC | CG | GG | CC + CG vs. GG (dominant) | CG + GG vs. CC (recessive) | GG vs. CC(homozygote) | GG vs. CG(heterozygote) | |
| Gender | |||||||
| Male | 85/97 | 127/124 | 43/44 | 1.02 (0.64-1.62); P = 0.937 | 0.87 (0.60-1.24); P = 0.435 | 0.90 (0.54-1.50); P = 0.676 | 1.05 (0.64-1.71); P = 0.851 |
| Female | 98/121 | 164/157 | 57/53 | 1.14 (0.76-1.72); P = 0.528 | 0.77 (0.56-1.06); P = 0.116 | 0.75 (0.48-1.19); P = 0.226 | 0.97 (0.63-1.50); P = 0.895 |
| Gender a | |||||||
| Male | 85/97 | 127/124 | 43/44 | 0.97 (0.61-1.56); P = 0.914 | 0.89 (0.61-1.29); P = 0.527 | 0.96 (0.56-1.65); P = 0.883 | 1.08 (0.66-1.77); P = 0.767 |
| Female | 98/121 | 164/157 | 57/53 | 1.17 (0.77-1.77);P = 0.474 | 0.76 (0.55-1.06); P = 0.106 | 0.75 (0.47-1.21); P = 0.240 | 0.95 (0.61-1.48); P = 0.830 |
| Age | |||||||
| < 65 | 23/15 | 32/35 | 14/10 | 1.27 (0.52-3.12); P = 0.598 | 1.50 (0.70-3.24); P = 0.302 | 1.10 (0.39-3.10); P = 0.864 | 0.65 (0.25-1.68); P = 0.376 |
| ≥ 65 | 160/203 | 259/246 | 86/87 | 1.06 (0.76-1.47); P = 0.729 | 0.76 (0.59-0.98); P = 0.036 | 0.80 (0.56-1.15); P = 0.221 | 1.07 (0.75-1.50); P = 0.720 |
| Age b | |||||||
| < 65 | 23/15 | 32/35 | 14/10 | 1.48 (0.58-3.77); P = 0.415 | 1.70 (0.76-3.79); P = 0.199 | 1.11 (0.34-3.66); P = 0.861 | 0.57 (0.21-1.53); P = 0.261 |
| ≥ 65 | 160/203 | 259/246 | 86/87 | 1.04 (0.74-1.45); P = 0.836 | 0.75 (0.58-0.98); P = 0.032 | 0.81 (0.56-1.17); P = 0.257 | 1.09 (0.77-1.56); P = 0.618 |
| BMI | |||||||
| < 18.5 | 2/14 | 12/14 | 3/6 | 1.00 (0.22-4.61); P = 1.000 | 0.19 (0.04-0.97); P = 0.046 | 0.29 (0.04-2.17); P = 0.226 | 1.71 (0.35-8.37); P = 0.505 |
| 18.5- | 72/104 | 100/129 | 37/45 | 1.11 (0.69-1.80); P = 0.658 | 0.88 (0.60-1.28); P = 0.501 | 0.84 (0.50-1.43); P = 0.524 | 0.94 (0.57-1.57); P = 0.820 |
| ≥ 24 | 109/100 | 179/138 | 60/46 | 1.08 (0.71-1.64); P = 0.727 | 0.84 (0.60-1.17); P = 0.301 | 0.84 (0.52-1.34); P = 0.454 | 0.99 (0.64-1.55); P = 0.980 |
| BMI c | |||||||
| < 18.5 | 2/14 | 12/14 | 3/6 | 1.07 (0.22-5.29); P = 0.934 | 0.16 (0.03-0.89); P = 0.037 | 0.16 (0.01-2.54); P = 0.193 | 1.89 (0.35-10.22); P = 0.461 |
| 18.5- | 72/104 | 100/129 | 37/45 | 1.04 (0.64-1.70); P = 0.870 | 0.90 (0.62-1.32); P = 0.604 | 0.92 (0.53-1.60); P = 0.779 | 0.99 (0.59-1.66); P = 0.966 |
| ≥ 24 | 109/100 | 179/138 | 60/46 | 1.09 (0.71-1.67); P = 0.696 | 0.83 (0.59-1.16); P = 0.263 | 0.83 (0.51-1.34); P = 0.437 | 1.00 (0.64-1.56); P = 0.987 |
Bold values are statistically significant (P < 0.05). a Adjusted for age, BMI, and WHR; b Adjusted for gender, BMI, and WHR; c Adjusted for age, gender, and WHR.