Table 5.
The meta-analysis of the association between T2DM and miR-146a rs2910164.
| Genetic variant | Ethnicity | No. | Test of heterogeneity | Test of association (FE model) | Test of association (RE model) | P* | |||
|---|---|---|---|---|---|---|---|---|---|
| I 2 | P | OR (95% CI) | P | OR (95% CI) | P | ||||
| CC + CG vs. GG (dominant) | Overall | 6 | 66.4 | 0.011 | 1.10 (0.95-1.26) | 0.206 | 1.09 (0.83-1.42) | 0.533 | 0.932 |
| Asian | 4 | 76.4 | 0.005 | 1.09 (0.93-1.28) | 0.305 | 1.07 (0.74-1.55) | 0.714 | ||
| Caucasian | 2 | 54.1 | 0.140 | 1.12 (0.83-1.51) | 0.445 | 1.11 (0.72-1.73) | 0.631 | ||
| CC vs. CG + GG (recessive) | Overall | 6 | 76.0 | 0.001 | 1.10 (0.98-1.23) | 0.106 | 1.15 (0.87-1.53) | 0.337 | 0.602 |
| Asian | 4 | 81.3 | 0.001 | 1.07 (0.95-1.20) | 0.268 | 1.04 (0.76-1.41) | 0.808 | ||
| Caucasian | 2 | 4.0 | 0.307 | 1.79 (1.08-2.96) | 0.023 | 1.78 (1.06-2.98) | 0.029 | ||
| CC vs.GG (homozygote) | Overall | 6 | 72.8 | 0.002 | 1.32 (1.12-1.56) | 0.001 | 1.38 (0.95-1.99) | 0.088 | 0.712 |
| Asian | 4 | 80.5 | 0.001 | 1.27 (1.07-1.52) | 0.007 | 1.27 (0.81-1.98) | 0.292 | ||
| Caucasian | 2 | 34.7 | 0.216 | 1.79 (1.07-3.00) | 0.027 | 1.75 (0.91-3.35) | 0.092 | ||
| CG vs. GG (heterozygote) | Overall | 6 | 52.1 | 0.063 | 1.20 (1.03-1.39) | 0.018 | 1.20 (0.95-1.51) | 0.128 | 0.993 |
| Asian | 4 | 60.3 | 0.056 | 1.26 (1.07-1.50) | 0.007 | 1.31 (0.97-1.76) | 0.079 | ||
| Caucasian | 2 | 10.6 | 0.290 | 0.98 (0.71-1.36) | 0.921 | 0.98 (0.70-1.36) | 0.923 | ||
| C vs. G (allele) | Overall | 6 | 77.3 | 0.001 | 1.21 (1.03-1.21) | 0.006 | 1.13 (0.93-1.35) | 0.213 | 0.883 |
| Asian | 4 | 83.6 | 0.000 | 1.10 (1.01-1.20) | 0.021 | 1.09 (0.87-1.37) | 0.441 | ||
| Caucasian | 2 | 67.4 | 0.080 | 1.23 (0.97-1.55) | 0.089 | 1.21 (0.80-1.83) | 0.369 | ||
Number of studies (No.), type 2 diabetes mellitus (T2DM), random effects (RE), fixed effects (FE). *: Test for publication bias (Egger’s test).