. 2022 Oct;192(10):1358–1367. doi: 10.1016/j.ajpath.2022.06.007

Table 3.

EV-Derived Molecules Involved in Liver Tumorigenesis

Pathology changes	Molecules
EMT	• ZEBs⁵⁷ • N-cadherin⁵⁷ • α-SMA⁵⁷ • Vimentin⁵⁷ • OVOL1 (negative effect)⁵⁷ • HGF⁵⁸
Angiogenesis	• miR-21⁵⁵ • ANGPT2⁵⁹ • Vasorin⁶⁰ • miR-155⁶¹ • miR-210⁶² • Circ-CCAC1⁶³ • lncRNA H19⁶⁴ • CircRNA-100338⁶⁵
Proliferation, invasion, and metastasis	• CircRNA-100338⁶⁵ • miR-181d-5p⁶⁶ • lncRNA-TUC339⁶⁷ • ITG-αMβ2 and CD147⁶⁸ • lncRNA-FAL1 and miR-1236⁶⁹ • miR-21 and miR-10b⁷⁰^,⁷¹ • miR-103⁷² • linc-ROR⁷³

Listed molecules are increased in EVs under the disease status.

ANGPT2, angiopoietin 2; Circ-CCAC1, circular RNA 1; CircRNA, circular RNA; EMT, epithelial-mesenchymal transition; EV, extracellular vesicle; HGF, hepatocyte growth factor; ITG-αMβ2, integrin αMβ2; linc-ROR, long intergenic non–protein-coding RNA, regulator of reprogramming; lncRNA, long ncRNA; ncRNA, noncoding RNA; OVOL1, ovo like transcriptional repressor 1; α-SMA, α-smooth muscle actin; ZEB, zinc finger E-box binding homeobox.