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. 2022 Oct;192(10):1358–1367. doi: 10.1016/j.ajpath.2022.06.007

Table 4.

EV-Derived Molecules with Potential Diagnostic Values for Liver Cancers

Molecules Examples
Proteins
  • GAL-3BP81

  • PIGR81

  • SMAD382

  • CAP183

miRNAs
  • miR-21062

  • miR-2171

  • miR-22484

  • miR-9385

  • miR-21-5p86

  • miR-10b-5p/miR-221-3p/miR-223-3p86

  • miR-125b87

  • miR-18a88

  • miR-22188

  • miR-22288

  • miR-22488

  • miR-10188

  • miR-106b88

  • miR-12288

  • miR-19588

lncRNAs and lincRNAs
  • lncRNA H1964

  • ncRNA-TUC33967

  • lnc-ROR73

  • VLDLR-AS189

  • Linc-0016190

Listed molecules are increased in EVs under the disease status, except those marked with an asterisk.

CAP1, cytoskeleton regulatory protein 1; EV, extracellular vesicle; GAL-3BP, galectin-3–binding protein; lincRNA, long intergenic noncoding RNAs; lncRNA, long ncRNA; lnc-ROR, long intergenic non-protein coding RNA, regulator of reprogramming; ncRNA, noncoding RNA; PIGR, polymeric immune receptor; SMAD3, SMAD family member 3; VLDLR-AS1: VLDLR antisense RNA 1.

Molecules that are reduced under the disease status.