TABLE 1.
Frequencies of the TPMT and NUDT15 alleles/phenotypes in major race/ethnic groups.
| — | Allele | African | Central/South Asian | East Asian | European | Phenotype | African | Central/South Asian | East Asian | European |
|---|---|---|---|---|---|---|---|---|---|---|
| TPMT | *1 | 92.34% | 98.14% | 97.96% | 95.31% | NM | 85.27% | 96.31% | 95.97% | 90.84% |
| *2 | 0.53% | 0.02% | 0.01% | 0.21% | IM | 6.89% | 3.41% | 3.34% | 8.42% | |
| *3A | 0.80% | 0.42% | 0.03% | 3.43% | PIM | 0.29% | 0.00% | 0.01% | 0.02% | |
| *3B | 0.00% | 0.17% | 0.00% | 0.27% | PM | 0.14% | 0.03% | 0.03% | 0.20% | |
| *3C | 2.40% | 1.12% | 1.64% | 0.47% | Indeterminate | 7.41% | 0.24% | 0.65% | 0.53% | |
| NUDT15 | *1 | 99.69% | 93.00% | 87.90% | 99.31% | NM | 99.38% | 86.49% | 77.26% | 0.53% |
| *2 | 0.00% | 14.3% | 3.50% | 0.00% | IM | 0.27% | 12.55% | 16.79% | 8.42% | |
| *3 | 0.10% | 6.70% | 6.05% | 0.20% | PIM | 0.00% | 0.03% | 0.49% | 90.84% | |
| *4 | 0.03% | 0.00% | 0.09% | 0.00% | PM | 0.00% | 0.46% | 0.91% | 0.20% | |
| *5 | 0.00% | 0.04% | 1.11% | 0.00% | Indeterminate | 0.35% | 0.46% | 4.55% | 0.02% | |
| *6 | 0.15% | 0.20% | 1.30% | 0.30% |
NM: Normal metabolizer; IM: Intermediate metabolizer; PIM: Possible intermediate metabolizer; PM: Poor metabolizer.
Data from PharmGKB (https://www.pharmgkb.org) and study of Banerjee R and colleagues (Banerjee et al., 2020).