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. 2022 Sep 26;24(39):7082–7087. doi: 10.1021/acs.orglett.2c02592

Table 2. Optimization of ERED–110-Catalyzed Bioreduction of Chloroenone 1a to Obtain (R)-2a.

entrya 2-PrOH (% vol) T (°C) t (h) c (%)b ee (%)c
1 2.5 30 4 90 91
2 5.0 30 4 97 93
3 7.5 30 4 83 94
4 10.0 30 4 86 94
5 5.0 25 4 >99 97
6 5.0 25 3 >99 98
7 5.0 25 2 94 95
a

For further details, see Tables S5 and S6.

b

Determined by GC.

c

Determined by HPLC.