Table III.
Comparison of immune cell profiles among severe, mild symptomatic, patients not requiting O2 support (asymptomatic+mild symptomatic) and patients requiting O2 support (moderate + severe) patients with SARS-CoV-2 infection
| Cell type | Patients not requiting O2 support (asymptomatic + mild symptomatic [n=89]) | Patients requiting O2 support (moderate + severe [n=30]) | Mild symptomatic (n=36) | Severe (n=15) |
|---|---|---|---|---|
| NK and NKT-like cell profile | ||||
| CD3-CD56+NK cells | 2.21 (0.1-10.4) | 12.5 (0.5-48.4)* | 2.27 (0.2-10.4) | 10.9 (0.57-33)$ |
| CD3+CD56+NKT-like cells | 11.4 (0-65) | 9.93 (1.2-30.7)* | 9.59 (0-62.4) | 11.0 (1.2-30.7)$ |
| T cell profile | ||||
| CD3+CD4+Th cells | 68.9 (44.3-92.4) | 59.7 (4.19-86.2)* | 71.7 (44.3-92.4) | 57.6 (4.1-85.1)$ |
| CD3+CD8+TcCells | 21.4 (0.2-43.6) | 19.5 (1.9-67.2) | 18.6 (2.9-41.1) | 17.3 (5.8-32.2) |
Percentage of each cell type are represented as mean (range). P* <0.05 compared to patients not requiring O2 support; P$ <0.05 compared to mild symptomatic