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. 2022 Oct 11;11:106. doi: 10.1186/s40249-022-01032-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Estimated burden of chronic hepatitis B infection in China. A The number of chronic HBV infections and chronic hepatitis B (CHB) cases; B The estimated proportion of mother-to-child transmission account for the total number of chronic HBV infections; C the number of chronic HBV infections that were less than 5 years old. Note: chronic HBV infection is defined as a dynamic process with HBsAg and/or HBV DNA positivity for more than 6 months, reflecting the interaction between HBV replication and the host immune response; while CHB is defined as a chronic inflammatory disease of the liver caused by persistent HBV infection. HBV Hepatitis B virus