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. 2022 Oct 11;27:91. doi: 10.1186/s11658-022-00376-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Depletion of the LINC00240 reversed the roles of LARRPM in proliferation, apoptosis, migration and invasion of LUAD cells. a LARRPM and LINC00240 expression in A549 cells with LARRPM overexpression; LINC00240 depletion was detected by qRT-PCR. b, c Cell proliferation of A549 cells with LARRPM overexpression and LINC00240 depletion was detected using the CCK-8 assay (b) and EdU incorporation assay (c). Scale bar: 100 µm. Red color indicates the EdU-positive cells. d, e Cell apoptosis of A549 cells with LARRPM overexpression and LINC00240 depletion was detected using the caspase-3 activity assay (d) and TUNEL assay (e). Scale bar: 100 µm. Green color indicates TUNEL-positive cells. f, g Cell migration and invasion of A549 cells with LARRPM overexpression and LINC00240 depletion were detected using the transwell migration assay (f) and transwell invasion assay (g). Scale bar: 100 µm. Results are shown as the mean ± SD based on three independent experiments. Asterisks indicate a significant difference at *P < 0.05, **P < 0.01, ***P < 0.001; ns, not significant, by one-way ANOVA followed by Dunnett's multiple comparisons test