Figure 2.

Cells with 11q loss are more sensitive to prexasertib treatment. (A) Ideogram of chromosome 11q and approximate deletions (represented by the absence of a colored bar) in the panel of NB cell lines used in this study. (B) Box plot of IC₅₀ values following 72-hour prexasertib treatment in 11q del (blue) and 11q wild type (grey) cell lines. Statistical significance is reached (Mann Whitney U test, p=0.03). (C) Cell cycle distribution of 11q deleted (CHLA-90 and Gimen) and 11q wild type (SH-SY5Y) cells following 72-hour incubation with 5 nM of prexasertib.