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. Author manuscript; available in PMC: 2022 Oct 11.
Published in final edited form as: Life Sci. 2010 Nov 1;88(1-2):74–81. doi: 10.1016/j.lfs.2010.10.026

Fig. 6.

Fig. 6.

Effect of daily treatment with endostatin (2 mg/100 g, s.c.) on DSS-induced UC in MMP-9 KO mice. (A) Changes in body weight. Mean body weight on the 1st day represents 100%. (B) Clinical score. Results are expressed as mean±SD; n = 5 mice/group. ** p < 0.001; *** p < 0.0001 vs. control (saline). (C, D) Histologic changes in the colon during DSS-induced UC in MMP-9 KO mice treated with saline (×40) or endostatin (×100) (H&E staining). (C) Mice after DSS ingestion show that the normal colonic mucosa is almost completely replaced by massive inflammatory cell infiltration and early granulation tissue (arrows). (D) Endostatin-treated mice with DSS revealed intact normal mucosa and moderate submucosal edema (arrows).