Table 4.

Role of NLRP3 in other types of I/R Injury.

Disease	Supplementation	Human/animal study	Cell line	NLRP3 expression	Target/signaling pathway	Observation	Ref
Limb I/R Injury (LI/R)	Hydrogen-Rich Saline (HRS)	Male Wistar Rats; treated with 2.5 and 10 mL/kg HRS, IP, immediately after the femoral artery occlusion		Up	CHEMERIN, IL-6, TNF-α, MDA, SOD	HRS decreases acute limb I/R-induced lung injury through decreasing levels of chemerin and NLRP3.	(86)
Femoral Artery Ligation (FAL)	–	Male C57BL/6 Mice	–	Up	TLR4, IL-1β, Caspase-1	The platelet NLRP3 inflammasome could promote platelet aggregation.	(87)
Renal I/R Injury	–	Male C57BL/6J Mice, Human Kidney Biopsy Specimens		Up	–	NLRP3 is overexpressed in chronic kidney disease after I/R induced-acute renal injury.	(88)
Testicular I/R Injury	–	Male C57BL/6J Mice, KO Mice	–	–	Caspase-1/3, IL-1β/18	NLRP3 inflammasome participates in the impairment of spermatogenesis following testicular I/R.	(89)