TABLE 3.
Key DEGs in heart transcriptome of E. sinensis.
| Category | Gene name | Gene definition | log2Foldchange | padj |
|---|---|---|---|---|
| Regeneration | ACTA2 | Actin, aortic smooth muscle | 1.537 | 0.008 |
| COX15 | Cytochrome c oxidase assembly protein COX15 homolog | 1.133 | 0.014 | |
| ARPP21 | cAMP-regulated phosphoprotein 21 | 1.609 | 0.021 | |
| FZD1 | Frizzled-1 | 2.029 | 0.031 | |
| IQGAP1 | Ras GTPase-activating-like protein IQGAP1 | 4.369 | 0.000 | |
| CNN1 | Calponin-1 | 2.489 | 0.002 | |
| FZD7 | Frizzled-7 | 3.668 | 0.000 | |
| BAP60 | Brahma-associated protein of 60 kDa | 7.206 | 0.000 | |
| WNT2 | Protein Wnt-2 | 3.262 | 0.005 | |
| WNT5B | Protein Wnt-5b | 5.171 | 0.020 | |
| NMDAR1 | Glutamate [NMDA] receptor subunit 1 | 6.389 | 0.001 | |
| ATP2B2 | Plasma membrane calcium-transporting ATPase 2 | 5.779 | 0.005 | |
| NTRK2 | BDNF/NT-3 growth factors receptor | 6.034 | 0.003 | |
| ECR | Ecdysone receptor | -5.224 | 0.019 | |
| UNC-22 | Twitchin | 6.974 | 0.000 | |
| NOS1AP | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein | 8.685 | 0.000 | |
| BIN1 | Myc box-dependent-interacting protein 1 | 1.107 | 0.031 | |
| TIM | Protein timeless | 2.210 | 0.045 | |
| Antioxidation and anti-aging | GCLC | Glutamate--cysteine ligase catalytic subunit | 3.617 | 0.000 |
| GGT1 | Glutathione hydrolase 1 proenzyme | 1.256 | 0.000 | |
| GSTD1 | Glutathione S-transferase 1, isoform C | 6.480 | 0.001 | |
| DJR-1.1 | Glutathione-independent glyoxalase DJR-1.1 | 8.008 | 0.000 | |
| ERCC2 | General transcription and DNA repair factor IIH helicase subunit XPD | 3.737 | 0.000 | |
| ALDH3A1 | Aldehyde dehydrogenase, dimeric NADP-preferring | 3.037 | 0.000 | |
| DAO | D-amino-acid oxidase | -2.806 | 0.034 | |
| RAD3 | The general transcription and DNA repair factor IIH helicase subunit XPD | 3.23 | 0.002 | |
| ENOX2 | Ecto-NOX disulfide-thiol exchanger 2 | 8.626 | 0.000 | |
| NAMPT | Nicotinamide phosphoribosyltransferase | 2.080 | 0.005 | |
| Immune response regulaiton | ITGA4 | Integrin alpha-4 | 4.098 | 0.000 |
| ATG5 | Autophagy protein 5 | 1.488 | 0.019 | |
| KIFAP3 | Kinesin-associated protein 3 | 4.712 | 0.047 | |
| LGMN | Legumain | 2.024 | 0.000 | |
| NFYC | Nuclear transcription factor Y subunit gamma | 1.286 | 0.002 | |
| PCNA | Proliferating cell nuclear antigen | 2.856 | 0.000 | |
| SPON2 | Spondin-2 | 1.567 | 0.000 | |
| CBLB | E3 ubiquitin-protein ligase CBL-B | 6.695 | 0.000 |