Table 1.
Functional role of DUBs in different parasites.
| Species Name | GenbankID/UniProtKB/VEuPathDB | Class (DUB domain) | DUBs | Function for Drug target | Ref. |
|---|---|---|---|---|---|
| Schistosoma mansoni | XP_018650214.1 | MJD | Ataxin-3 | Involved in life cycle | (Stirewalt, 1974), (Fishelson et al., 1992) |
| Schistosoma mansoni | XP_018645017.1 | USP | USP14 | It found in different life cycle stages indicating their involvement in cellular processes required for S.mansoni development | (Pereira et al., 2015a), (do Patrocinio et al., 2020) |
| Trichinella Spiralis | 157958881 | UCH | UCHL5 | Deubiquitination activities | (Song et al., 2018) |
| Trichinella Spiralis | 13182314 | OTU | OTU68 | Protein degradation | (White et al., 2011) |
| Plasmodium falciparum | Gene - PfNF54_110021400 | UCH54/NF54 | PfUCH54 | Deubiquitinating as well as deNeddylating activities | (Artavanis-Tsakonas et al., 2006) |
| Plasmodium falciparum | Gene - PfNF135_140064500 | UCHL3 | PfUCHL3 | Essential for the survival of the parasite | (Frickel et al., 2007) |
| Plasmodium falciparum | Gene - PF3D7_1031400 | OTU | mOTU | It helps in the entry of plasmodium into the host cell | (Hunt et al., 2007) |
| Toxoplasma gondii | XP_002365447.1 | UCH | TgUCHL3 | Deubiquitinating as well as deNeddylating activity and protein degradation, the cell cycle and transcription progression of the cell cycle | (De Monerri et al., 2015) |
| Toxoplasma gondii | A0A7J6K192 | OTU | TgOTUD3A | Plasticity of apicomplexan cell cycle architecture.A novel regulator of dendritic cells during infectious and inflammatory diseases. | (Mulas et al., 2021) (Dhara et al., 2017), |
|
Eimeria
tenella |
XM_013374305.1 | OTU | Et-OTU | Expression at different phase of Eimeria tenella life cycle and also regulate E. tenella telomerase activity | (Wang et al., 2018) |
| Cryptosporidium parvum | XM_001388292.1 | OTU | CpOTU | Phathophysiological role in oocyst stage of the parasite and isopeptidase activity. | (Ju et al., 2014) |
| Leishmania infantum | A4HXL8 | OTU | OTULi | Proinflammatory response in stimulated murine macrophages | (Azevedo et al., 2017) |
| Trypanosoma cruzi | A0A7J6YC36 | COP9 | – | Cell cycle regulation. | (Ghosh et al., 2020) |
| Nosema bombycis | R0KME3 | OTU | NbOTU1 | Protein degradation, signal transduction, cell immune response, and deubiquitination activity in vitro. | (Wang et al., 2015) |