Table 3.
Sequence Identity and query coverage by in-silico (BLAST) analysis of different identified DUB domains of parasites compared to humans.
| Parasite | USP14 | USP7 | USP2a | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Query coverage | % Identity | Accession ID | Query coverage | % Identity | Accession ID | Query coverage | % Identity | Accession ID | |
| Plasmodium falciparum | 87% | 33.19% | ETW53368.1 | 44% | 36.28% | ETW37327.1 | 53% | 35.83% | ETW50834.1 |
| Schistosoma mansoni | 77% | 41.91% | XP_018645017.1 | 82% | 48.33% | XP_018648322.1 | 55% | 46.28% | XP_018650394.1 |
| Leishmania donovani | 97% | 29.61% | XP_003863105.1 | 44% | 35.51% | AYU82972.1 | 54% | 31.85% | XP_003861970.1 |
| Eimeria acervulina | 58% | 34.33% | XP_013246507.1 | 26% | 41.18% | XP_013250312.1 | 55% | 38.83% | XP_013253187 |
| Toxoplasma gondii | 98% | 30.14% | KYK69963.1 | 33% | 37.46% | KFG53298.1 | 29% | 38.92% | KFG34937.1 |
| Trichinella spiralis | 96% | 44.65% | XP_003375066.1 | 94% | 48.33% | KRY40700.1 | 46% | 42.19% | XP_003380019.1 |
| Nosema bombycis | ABSENT | 29% | 35.24% | EOB14601.1 | ABSENT | ||||
| Cryptosporidium parvum | 99% | 31.78% | QOY43601.1 | 37% | 38.79% | XP_627060.1 | 54% | 30.88% | QOY42883 |
| Trypanosoma cruzi | 97% | 33.87% | KAF8294020.1 | 32% | 38.50% | PWU84353.1 | 54% | 34.55% | EKJ03440.1 |
| Parasite | USP28 | CYLD | A20 | ||||||
| Query coverage | % Identity | Accession ID | Query coverage | % Identity | Accession ID | Query coverage | % Identity | Accession ID | |
| Plasmodium falciparum | 8% | 31.82% | KOB64092.1 | ABSENT | ABSENT | ||||
| Schistosoma mansoni | 31% | 25.26% | XP_018648322.1 | ABSENT | 27% | 30.63% | XP_018651129.1 | ||
| Leishmania donovani | 27% | 25.98% | AYU82972.1 | ABSENT | ABSENT | ||||
| Eimeria acervulina | 4% | 35.85% | XP_013250312.1 | ABSENT | ABSENT | ||||
| Toxoplasma gondii | 4% | 39.62% | KGF53298.1 | ABSENT | ABSENT | ||||
| Trichinella spiralis | 29% | 27.20% | KRY40700.1 | 41% | 37.22% | KRY38886.1 | 34% | 33.86% | KRY33887.1 |
| Nosema bombycis | 31% |
25.37% |
EOB14601.1 |
ABSENT | ABSENT | ||||
| Cryptosporidium parvum | ABSENT | ABSENT | ABSENT | ||||||
| Trypanosoma cruzi | 21% | 29.20% | EKF30393.1 | ABSENT | ABSENT | ||||
| Parasite | UCHL3 | ATAXIN3 | USP2a | ||||||
| Query coverage | % Identity | Accession ID | Query coverage | % Identity | Accession ID | Query coverage | % Identity | Accession ID | |
| Plasmodium falciparum | 96% | 33.33% | ETW54267.1 | 46% | 32.94% | ETW17560.1 | 53% | 35.83% | ETW50834.1 |
| Schistosoma mansoni | 77% | 43.09% | XP_018651143.1 | 78% | 41.72% | XP_018650214.1 | 55% | 46.28% | XP_018650394.1 |
| Leishmania donovani | 96% | 36.24% | XP_003861350.1 | ABSENT | 54% | 31.85% | XP_003861970.1 | ||
| Eimeria acervulina | 65% | 27.71% | XP_013251940.1 | ABSENT | 55% | 38.83% | XP_013253187 | ||
| Toxoplasma gondii | 100% | 36.36% | XP_002365447.1 | 55% | 35.52% | KHF17592.1 | 29% | 38.92% | KFG34937.1 |
| Trichinella spiralis | 96% | 26.69% | KRY33554.1 | 80% | 38.39% | XP_003374686.1 | 46% | 42.19% | XP_003380019.1 |
| Nosema bombycis | ABSENT | ABSENT | ABSENT | ||||||
| Cryptosporidium parvum | 90% | 28.44% | XP_627216.1 | 61% | 31.74% | XP_627894.1 | 54% | 30.88% | QOY42883 |
| Trypanosoma cruzi | 97% | 39.39% | XP_816838.1 | ABSENT | 54% | 34.55% | EKJ03440.1 | ||