Table 5.

Top 3 clusters identified, respectively, from MCODE results of YGJ and YGJ-BBB.

Group	Cluster	Pathway description	Targets	Count	Score
YGJ	1	Dopaminergic synapse	APP, DRD4, HCAR2, CCR2, MTNR1B, DRD3, OPRM1, MTNR1A, DRD2, CNR1	10	4.50
	2	EGFR tyrosine kinase inhibitor resistance	PDGFRB, KIT, MAPT, LRRK2, MAP2K1, PRKCD, NTRK1, PIK3CA, ERBB2, RET, JAK2, VEGFA, ESR1, MTOR, IGF1R, STAT3, BRAF, IL2, GSK3B, FGFR1, HDAC6	21	4.48
	3	Calcium signaling pathway	ESR2, HTR2A, INSR, NOS2, HTR2C, MCL1, VCP, ERBB4, SNCA, AGTR1, F2, HRH1, TERT, ROCK2, EGFR, HSP90AA1, MAPK1, CCKBR	18	2.61
YGJ-BBB	1	Rap1 signaling pathway	DRD3, PDGFRB, MTNR1B, CCR2, DRD4, HCAR2, DRD2, MTNR1A, OPRM1, KIT, CNR1, IL2, MAP2K1, JAK2	14	3.14
	2	MAPK signaling pathway	NTRK1, ESR1, EGFR, STAT3, ERBB2, IGF1R	6	2.33
	3	HIF-1 signaling pathway	MTOR, BRAF, MAPK1, ROCK2, INSR, PIK3CA, NOS2, HSP90AA1, TERT, FGFR1	10	2.10