Figure 5.

Corneal physiological parameters were not compromised during AAV5-Id3 gene therapy to the corneal tissues

(A) Schirmer tear test graph shows that AAV5-Id3 gene therapy does not vary the normal secretion of ocular flow compared with the naive and AAV5-naked vector groups. The tear flow manifestly increased after day 1 and reverted to normal on day 3 in well-defined limitation of topical gene therapy. (B) Pachymetry graph shows that corneal thickness was constant throughout the study in a time-dependent manner in naive, AAV5-naked, and AAV5-Id3 corneal tissue groups. The corneal thickness increased after day 1 and reverted to normal on day 7 in well-defined limitation of topical gene therapy. (C) Tonometry graph shows that intraocular pressure (IOP) is not a potential concern of AAV5-Id3 gene therapy. The IOP was constant and within the normal range in naive, AAV5-naked, and AAV5-Id3 groups of animals in a time-dependent manner. There were six samples in each group, and error bars represent ±SEM.