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. 2022 Sep 27;12:963096. doi: 10.3389/fonc.2022.963096

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Copyright © 2022 Dong, Zhang, Zhang, Wang, Liu, Wang, Hao, Tan and Chang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of hepcidin-interacting genes and proteins. (A) The gene–gene interaction network of hepcidin was constructed using GeneMANIA. (B) The PPI network of hepcidin was generated using STRING. (C, D) A heatmap shows the correlations between hepcidin and iron metabolism-related genes in LGG (C) and GBM (D). (E) The gene circle map of hepcidin from the co-expression analysis. Red lines represent positive correlations with hepcidin, and green lines represent negative correlations with hepcidin. *p < 0.05 and **p < 0.01.