Table 3. Symptoms Reported Among Symptomatic People Testing Positive or Negative With a Rapid Antigen Test During the Omicron BA.1 Period,a Stratified by Vaccination Status.
| Symptoms | Overall (n = 5424) | No. (%) of participants | P value (B-H corrected) | Point estimate (95% CI) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Unvaccinated (n = 233) | Vaccinated | ||||||||||
| Positive (n = 116) | Negative (n = 117) | Not boosted (n = 3817) | Boosted (n = 1374) | Boosted vs unvaccinated among COVID-positive patients | Boosted vs vaccinated not boosted among COVID-positive patients | Boosted vs unvaccinated among COVID-positive patients | Boosted vs vaccinated not boosted among COVID-positive patients | ||||
| Positive (n = 1705) | Negative (n = 2112) | Positive (n = 432) | Negative (n = 942) | ||||||||
| Fever | 1162 (21.4) | 42 (36.2) | 16 (13.7) | 559 (32.8) | 343 (16.2) | 97 (22.5) | 105 (11.2) | .003 (.01) | <.001 (.01) | 0.62 (0.48-0.8) | 0.68 (0.57-0.83) |
| Cough | 3060 (56.4) | 71 (61.2) | 53 (45.3) | 1191 (69.9) | 1086 (51.4) | 268 (62.0) | 391 (41.5) | .87 (>.99) | .002 (.01) | 1.01 (0.94-1.1) | 0.89 (0.82-0.96) |
| Shortness of breath | 408 (7.5) | 10 (8.6) | 7 (6.0) | 150 (8.8) | 150 (7.1) | 36 (8.3) | 55 (4.8) | .92 (>.99) | .76 (.93) | 0.97 (0.68-1.37) | 0.95 (0.67-1.34) |
| Fatigue | 1144 (21.1) | 33 (28.5) | 25 (21.4) | 372 (21.8) | 410 (19.4) | 104 (24.1) | 200 (21.2) | .33 (.50) | .31 (.50) | 0.85 (0.7-1.02) | 1.10 (0.91-1.33) |
| Myalgia | 1383 (25.5) | 41 (35.3) | 25 (21.4) | 580 (34.0) | 440 (20.8) | 115 (26.6) | 182 (19.3) | .06 (.19) | .003 (.01) | 0.75 (0.64-0.89) | 0.78 (0.66-0.93) |
| Headache | 1921 (35.4) | 49 (42.2) | 42 (35.9) | 646 (37.9) | 719 (34.0) | 153 (35.4) | 312 (33.1) | .18 (.40) | .34 (.50) | 0.84 (0.73-0.97) | 0.93 (0.81-1.08) |
| Loss of taste or smell | 240 (4.4) | 12 (10.3) | 7 (6.0) | 99 (5.8) | 76 (3.6) | 25 (5.8) | 21 (2.2) | .08 (.22) | .99 (>.99) | 0.56 (0.37-0.86) | 1 (0.65-1.53) |
| Sore throat | 2325 (42.9) | 48 (41.4) | 34 (29.1) | 776 (45.5) | 850 (40.3) | 208 (48.2) | 409 (43.4) | .20 (.40) | .33 (.50) | 1.16 (1.04-1.30) | 1.06 (0.95-1.18) |
| Congestion | 2019 (37.2) | 40 (34.5) | 32 (27.4) | 668 (39.2) | 701 (33.2) | 207 (47.9) | 371 (39.4) | .010 (.04) | .001 (.01) | 1.39 (1.24-1.56) | 1.22 (1.09-1.37) |
| Nausea | 290 (5.4) | 7 (6.0) | 6 (5.1) | 89 (5.2) | 119 (5.6) | 18 (4.2) | 51 (5.4) | .39 (.50) | .37 (.50) | 0.69 (0.42-1.13) | 0.8 (0.49-1.31) |
| Diarrhea | 277 (5.1) | 10 (8.6) | 2 (1.7) | 83 (4.9) | 112 (5.3) | 21 (4.9) | 49 (5.2) | .12 (.29) | >.99 (>.99) | 0.56 (0.35-0.90) | 1 (0.63-1.59) |
Abbreviation: B-H, Benjamin-Hochberg.
a
December 1, 2021, to January 30, 2022.