Table 2.
List of significantly differentially expressed proteins between total stroke and healthy controls within 24 h of symptom onset using fold change with p-value and Boruta random forest feature selection criteria.
| S. No | UniProt ID | Protein name (Gene annotation) | Fold change* | P-value | Boruta decision |
|---|---|---|---|---|---|
| 1 | Q15848 | Adiponectin (GN = ADIPOQ) | 3.30 | 0.003 | Confirmed |
| 2 | P00450 | Ceruloplasmin (GN = CP) | 2.57 | 0.0002 | Confirmed |
| 3 | P04433 | Ig kappa chain V-III region VG (Fragment) | 2.54 | 0.01 | Rejected |
| 4 | P00739 | Haptoglobin-related protein (GN = HPR) | 2.18 | 0.04 | Rejected |
| 5 | P20851 | C4b-binding protein beta chain (GN = C4BPB) | 2.13 | 0.008 | Rejected |
| 6 | P04275 | von Willebrand factor (GN = VWF) | 2.12 | < 0.001 | Confirmed |
| 7 | P02750 | Leucine-rich alpha-2-glycoprotein (GN = LRG1) | 2.11 | 0.006 | Tentative |
| 8 | P05090 | Apolipoprotein D (GN = APOD) | 1.99 | 0.02 | Rejected |
| 9 | P02763 | Alpha-1-acid glycoprotein 1 (GN = ORM1) | 1.97 | 0.002 | Rejected |
| 10 | P04430 | Ig kappa chain V-I region BAN | 1.96 | 0.006 | Rejected |
| 11 | P05160 | Coagulation factor XIII B chain (GN = F13B) | 1.87 | 0.0007 | Confirmed |
| 12 | P06331 | Ig heavy chain V-II region ARH-77 | 1.86 | 0.0035 | Confirmed |
| 13 | P04114 | Apolipoprotein B-100 (GN = APOB) | 1.72 | 0.045 | Rejected |
| 14 | P01009 | Alpha-1-antitrypsin (GN = SERPINA1) | 1.63 | < 0.001 | Confirmed |
| 15 | P01023 | Alpha-2-macroglobulin (GN = A2M) | 1.58 | 0.002 | Rejected |
| 16 | P02746 | Complement C1q subcomponent subunit B (GN = C1QB) | 1.53 | 0.003 | Rejected |
| 17 | P02786 | Transferrin receptor protein 1 (GN = TFRC) | 1.52 | 0.003 | Confirmed |
| 18 | Q92820 | Gamma-glutamyl hydrolase (GN = GGH) | 1.28 | 0.03 | Confirmed |
| 19 | Q06033 | Inter-alpha-trypsin inhibitor heavy chain H3 (GN = ITIH3) | 1.26 | 0.0007 | Confirmed |
| 20 | P02790 | Hemopexin (GN = HPX) | 1.20 | 0.004 | Confirmed |
| 21 | P18428 | Lipopolysaccharide-binding protein (GN = LBP) | 1.20 | 0.0002 | Confirmed |
| 22 | P01011 | Alpha-1-antichymotrypsin (GN = SERPINA3) | 1.03 | 0.001 | Confirmed |
| 23 | P08185 | Corticosteroid-binding globulin (GN = SERPINA6) | 0.99 | 0.004 | Confirmed |
| 24 | P19827 | Inter-alpha-trypsin inhibitor heavy chain H1 (GN = ITIH1) | 0.98 | 0.06 | Confirmed |
| 25 | Q9UK55 | Protein Z-dependent protease inhibitor (GN = SERPINA10) | 0.85 | 0.073 | Confirmed |
| 26 | P08697 | Alpha-2-antiplasmin (GN = SERPINF2) | 0.78 | 0.006 | Confirmed |
| 27 | P01859 | Ig gamma-2 chain C region (GN = IGHG2) | 0.64 | 0.04 | Rejected |
| 28 | P05155 | Plasma protease C1 inhibitor (GN = SERPING1) | 0.51 | 0.001 | Confirmed |
| 29 | P06318 | Ig lambda chain V-VI region WLT | 0.50 | 0.03 | Tentative |
| 30 | P08253 | 72 kDa type IV collagenase (GN = MMP2) | 0.34 | 0.03 | Rejected |
| 31 | P0DJI8 | Serum amyloid A-1 protein (GN = SAA1) | 0.26 | 0.006 | Rejected |
*Fold change is a ratio representing the change of protein concentration between total stroke cases and healthy control subjects.
Bold values, Fold change >1.5 or < 0.67, p-value < 0.05 and confirmed/tentative in Boruta random forest.