Table 3.

List of significantly differentially expressed proteins between ischemic stroke and healthy controls using fold change with p-value and Boruta random forest feature selection criteria.

S. No	UniProt ID	Protein name (Gene annotation)	Fold change*	P-value	Boruta selection
1	Q15848	Adiponectin (GN = ADIPOQ)	3.30	0.02	Rejected
2	P05160	Coagulation factor XIII B chain (GN = F13B)	2.64	0.02	Rejected
3	P05090	Apolipoprotein D (GN = APOD)	1.99	0.01	Confirmed
4	P04003	C4b-binding protein alpha chain (GN = C4BPA)	1.95	0.02	Rejected
5	P00450	Ceruloplasmin (GN = CP)	1.81	0.02	Rejected
6	P04114	Apolipoprotein B-100 (GN = APOB)	1.72	0.01	Confirmed
7	P01009	Alpha-1-antitrypsin (GN = SERPINA1)	1.63	0.005	Confirmed
8	P01023	Alpha-2-macroglobulin (GN = A2M)	1.58	0.02	Confirmed
9	P02746	Complement C1q subcomponent subunit B (GN = C1QB)	1.53	0.04	Rejected
10	P02786	Transferrin receptor protein 1 (GN = TFRC)	1.52	0.04	Confirmed
11	P04275	von Willebrand factor (GN = VWF)	1.50	0.01	Rejected
12	Q13790	Apolipoprotein F (GN = APOF)	1.38	0.02	Confirmed
13	Q9UNW1	Multiple inositol polyphosphate phosphatase 1 (GN = MINPP1)	1.18	0.07	Confirmed
14	Q9Y2I9	TBC1 domain family member 30 (GN = TBC1D30)	0.74	0.01	Confirmed
15	Q99972	Myocilin (GN = MYOC)	0.66	0.04	Confirmed
16	P17936	Insulin-like growth factor-binding protein 3 (GN = IGFBP3)	0.09	0.03	Rejected

^*Fold change is a ratio representing the change of protein concentration between IS cases and healthy control subjects.

Bold values: Fold change >1.5 or < 0.67, p-value < 0.05 and confirmed/tentative in Boruta random forest.