Table 4.
List of significantly differentially expressed proteins between intracerebral hemorrhage and healthy controls using fold change with p-value and Boruta random forest feature selection criteria.
| S. No | UniProt ID | Protein name (Gene annotation) | Fold change* | P-value | Boruta decision |
|---|---|---|---|---|---|
| 1 | P01861 | Ig gamma-4 chain C region (GN = IGHG4) | 3.75 | 0.01 | Rejected |
| 2 | P27487 | Dipeptidyl peptidase 4 (GN = DPP4) | 3.52 | 0.05 | Rejected |
| 3 | P01880 | Ig delta chain C region (GN = IGHD) | 2.49 | 0.02 | Rejected |
| 4 | Q71U36 | Tubulin alpha-1A chain (GN = TUBA1A) | 2.43 | 0.04 | Rejected |
| 5 | P00450 | Ceruloplasmin (GN = CP) | 2.33 | 0.00 | Confirmed |
| 6 | P13796 | Plastin-2 (GN = LCP1) | 2.32 | 0.01 | Rejected |
| 7 | P01009 | Alpha-1-antitrypsin (GN = SERPINA1) | 2.31 | 0.00 | Rejected |
| 8 | P02649 | Apolipoprotein E (GN = APOE) | 2.30 | 0.20 | Confirmed |
| 9 | P01625 | Ig kappa chain V-IV region Len | 2.25 | 0.01 | Rejected |
| 10 | P36955 | Pigment epithelium-derived factor (GN = SERPINF1) | 2.21 | 0.004 | Confirmed |
| 11 | P04275 | von Willebrand factor (GN = VWF) | 2.15 | 0.003 | Tentative |
| 12 | P02750 | Leucine-rich alpha-2-glycoprotein (GN = LRG1) | 2.10 | 0.005 | Confirmed |
| 13 | P01833 | Polymeric immunoglobulin receptor (GN = PIGR) | 1.99 | 0.0004 | Confirmed |
| 14 | P09871 | Complement C1s subcomponent (GN = C1S) | 1.96 | 0.06 | Confirmed |
| 15 | P01613 | Ig kappa chain V-I region Ni | 1.95 | 0.01 | Rejected |
| 16 | P05160 | Coagulation factor XIII B chain (GN = F13B) | 1.89 | 0.01 | Rejected |
| 17 | P01701 | Ig lambda chain V-I region NEW | 1.86 | 0.02 | Rejected |
| 18 | P04430 | Ig kappa chain V-I region BAN | 1.80 | 0.01 | Rejected |
| 19 | P10643 | Complement component C7 (GN = C7) | 1.74 | 0.01 | Rejected |
| 20 | P02647 | Apolipoprotein A-I (GN = APOA1) | 1.72 | 0.01 | Rejected |
| 21 | P02763 | Alpha-1-acid glycoprotein 1 (GN = ORM1) | 1.70 | 0.01 | Rejected |
| 22 | P04217 | Alpha-1B-glycoprotein (GN = A1BG) | 1.69 | 0.01 | Tentative |
| 23 | Q06033 | Inter-alpha-trypsin inhibitor heavy chain H3 (GN = ITIH3) | 1.57 | 0.01 | Tentative |
| 24 | P00747 | Plasminogen (GN = PLG) | 1.54 | 0.01 | Rejected |
| 25 | P24592 | Insulin-like growth factor-binding protein 6 (GN = IGFBP6) | 1.52 | 0.0005 | Confirmed |
| 26 | P19827 | Inter-alpha-trypsin inhibitor heavy chain H1 (GN = ITIH1) | 1.48 | < 0.001 | Confirmed |
| 27 | Q9UK55 | Protein Z-dependent protease inhibitor (GN = SERPINA10) | 1.44 | 0.001 | Confirmed |
| 28 | P08697 | Alpha-2-antiplasmin (GN = SERPINF2) | 1.42 | 0.02 | Confirmed |
| 29 | P10909 | Clusterin (GN = CLU) | 1.27 | 0.02 | Confirmed |
| 30 | P06331 | Ig heavy chain V-II region ARH-77 | 1.23 | 0.004 | Tentative |
| 31 | P18428 | Lipopolysaccharide-binding protein (GN = LBP) | 1.23 | 0.01 | Tentative |
| 32 | P05155 | Plasma protease C1 inhibitor (GN = SERPING1) | 1.01 | 0.004 | Confirmed |
| 33 | P02654 | Apolipoprotein C-I (GN = APOC1) | 0.99 | 0.001 | Confirmed |
| 34 | P02652 | Apolipoprotein A-II (GN = APOA2) | 0.94 | 0.03 | Confirmed |
| 35 | P00746 | Complement factor D (GN = CFD) | 0.58 | 0.02 | Rejected |
| 36 | P25311 | Zinc-alpha-2-glycoprotein (GN = AZGP1) | 0.54 | 0.04 | Rejected |
| 37 | Q08380 | Galectin-3-binding protein (GN = LGALS3BP) | 0.51 | 0.03 | Rejected |
| 38 | Q15485 | Ficolin-2 (GN = FCN2) | 0.51 | 0.04 | Rejected |
| 39 | B9A064 | Immunoglobulin lambda-like polypeptide 5 (GN = IGLL5) | 0.40 | 0.01 | Confirmed |
| 40 | P35443 | Thrombospondin-4 (GN = THBS4) | 0.30 | 0.004 | Confirmed |
| 41 | P98160 | Basement membrane-specific heparan sulfate proteoglycan core protein (GN = HSPG2) | 0.21 | 0.02 | Rejected |
*Fold change is a ratio representing the change of protein concentration between ICH cases and healthy control subjects.
Bold values: Fold change >1.5 or < 0.67, p-value < 0.05 and confirmed/tentative in Boruta random forest.