Fig. 1.

Frequencies of clinical/cognitive features among the included participants. All cohorts had data about whether participants had normal cognition or dementia prior to death, and most (12 cohorts) had some measure for an intermediate clinical status, usually mild cognitive impairment (MCI). The finding of slightly over 40% cognitive normal prior to death is consistent with epidemiologic data of human populations in this age range [21, 60, 86, 90]. The result of each cohort was weighted equally in order to convey the cohort-to-cohort variance. For numbers of participants included from each cohort, see Table 1. Error bars denote 25th and 75th percentiles. *-MCI data were present for all cohorts except Vantaa 85 +