Fig. 5.

Findings in the 3803 participants with available LATE-NC stage data (a), Thal Aβ phases (b), and Braak NFT staging, which indicate an association between LATE-NC and PART pathology. A pie chart (a) shows the relative frequencies of the different LATE-NC stages. Note that ~ 25% of participants have LATE-NC stage 2 (21% of participants) or stage 3 (4% of participants). A separate pie chart (b) depicts the relative frequencies of different Thal Aβ phases. The bar chart in panel (c) shows the number of cases with Thal Aβ phase = 0, stratified by Braak NFT stages. In these brains lacking Aβ amyloid pathology, the presence of LATE-NC was associated with higher Braak NFT stages (more severe PART pathology). For exact numbers, see Table 5, and for a breakdown of the numbers of participants included from each cohort, see Supplemental Table 3, online resource