Fig. 6.

There is a tendency for LATE-NC to be associated with cognitive impairment, across a broad range of Braak NFT stages, in ten community-based cohorts. Data were gathered on cognitive status, stratifying by LATE-NC status and Braak NFT stages. Trends were evaluated from each cohort as to whether the cognitive status tended to be lower in persons with LATE-NC (down-going black arrow) or higher (up-going white arrow) in given Braak NFT stages. To operationalize global cognitive status, final Mini-Mental State Examination scores [33] were used, except HAAS used the Cognitive Abilities Screening Instrument [107] and the Brazil BAS and MCSA cohorts used the Clinical Dementia Rating sum of boxes scores [27]. There was a tendency for participants with LATE-NC to have lower cognition across the full range of Braak NFT stages