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. 2022 Oct 11;10(11):e707. doi: 10.1002/iid3.707

Figure 4.

Figure 4

TLR4 activation could reverse the inhibitory effect of n‐3 PUFAs on depression‐like behavior among mice. (A) Experimental schedule of mouse treatment. (B) Western blot detection of the expression of TLR4 protein in the hippocampus among mice. (C, D) TST and FST evaluation of the immobility time of mice. (E) SPT assessment of the sucrose preference of mice. **p < .01, ***p < .001. FST, forced swimming test; PUFAs, polyunsaturated fatty acids; SPT, sucrose preference test; TLR4, toll‐like receptor 4; TST, tail suspension test.