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. 2022 Sep 27;9:954087. doi: 10.3389/fmolb.2022.954087

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Copyright © 2022 Kieffer, Hilal, Gay, Debayle, Pronot, Poupon, Lacagne, Bardoni, Martin and Gwizdek.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bio-informatics analysis of the nuclear interactome of FMRP. (A). The list of the nuclear FMRP-interacting proteins was subjected to Uniprot Keywords (UP-KW) annotation analysis using the reviewed human homologues as data source: UP-KW for Cellular Components, UP-KW for Molecular functions, UP-KW for Biological process, and UP-KW for Diseases. Terms were ranked according to the number of proteins in the category. Details are available in Supplementary Table S4. (B) A network was built on physical interaction to complexes predicted by STRING using all identified FMRP-interacting proteins candidates as source, with an interaction confidence of 0.4 or greater and based on databases and experiments sources. The STRING network was imported into the Cytoscape application and clusters were created and annotated through the StringApp plug-in.