TABLE 1.

Ongoing clinical trials of drugs or devices for the treatment of congestion in HF.

Study	ClinicalTrials.gov identifier	Agent/Device	Clinical setting	Hypothesis
ADVOR trial (254)	NCT03505788	Acetazolamide	AHF	Acetazolamide improves decongestion when combined with loop diuretic therapy in AHF
AVANTI trial (255)	NCT03901726	Pecavaptan, a dual V1a/V2 AVP receptors antagonist	AHF	Pecavaptan improves decongestion when combined with loop diuretic therapy in AHF
TRANSFORM-HF trial (256)	NCT03296813	Torsemide	Stable HF	Torsemide comparative-effectiveness trial of torsemide versus furosemide
REVERSE-HF	NCT05318105	Ultrafiltration – Aquadex system	AHF	Ultrafiltration versus IV diuretics in worsening heart failure
DICTATE-AHF trial (257)	NCT04298229	Dapagliflozin	AHF	Efficacy and safety of initiating dapagliflozin within the first 24 h of hospitalization in patients with AHF compared to usual care
Reprieve cardiovascular system (258)	NCT05015764	Reprieve system	AHF	Reprieve system, which continuously monitors urine output and delivers a matched volume of hydration fluid sufficient to maintain the set fluid balance rate, compared with standard diuretic-based regimen improves decongestion in AHF
Aortix CRS pilot study	NCT04145635	Aortix pump	Cardiorenal syndrome	An elevation of the safety and performance of the Aortix system for intra-aortic mechanical circulatory support in patients with cardiorenal syndrome
SAHARA study	NCT04882358	Alfapump DSR system	Volume overloaded HF	Feasibility and safety study of the alfapump DSR system in the treatment of volume overloaded heart failure
DAPA ACT HF-TIMI 68	NCT04363697	Dapagliflozin	AHF	Effect of in-hospital initiation of dapagliflozin versus placebo on the clinical outcome of cardiovascular death or worsening heart failure
RELIEVE-HF trial (259)	NCT03499236	V-Wave Interatrial Shunt	Stable HF	Safety and effectiveness of the V-Wave Interatrial Shunt System for improving meaningful clinical outcomes in patients with NYHA functional class II, III, or ambulatory class IV HF