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. Author manuscript; available in PMC: 2022 Oct 11.
Published in final edited form as: Eur J Nucl Med Mol Imaging. 2022 May 12;49(11):3705–3716. doi: 10.1007/s00259-022-05814-9

Figure 2.

Figure 2.

Dynamic PET/CT using [68Ga]Ga-FAPI-46 in a murine model of bleomycin-induced lung fibrosis. (a) Mice were intratracheally given bleomycin or saline as a control, and dynamic PET/CT was performed at 7 d and 14 d following bleomycin. Whole-lung time activity curves at (b) 7 d and (c) 14 d showed significantly higher uptake in injured lung vs. control, 15 min post-injection of [68Ga]Ga-FAPI-46 (n = 3–5). Green arrows indicate lung volume. Lungs highlighted by yellow arrows. P values were calculated using Student’s two-tailed t-test (*P<0.05, **P<0.01, ***P<0.001).